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Successful Primary Oral Isavuconazole Therapy in Acute Invasive Fungal Sinusitis with Triple Fungal Species and Multiple Comorbidities.
Indian J Otolaryngol Head Neck Surg
February 2025
Department of Pathology, Naruvi Hospitals, Vellore, India.
Reporting the first successful treatment with oral Isavuconazole as primary antifungal agent following debridement, in an immunocompromised adult male with acute invasive fungal sinusitis involving multiple simultaneous fungal species. His comorbidities were retroviral and COVID infections, uncontrolled diabetes, ketoacidosis, and renal failure. A two-year follow-up revealed no recurrence.
View Article and Find Full Text PDFOutcomes of COVID-19-associated mucormycosis epidemic in India: A prospective 2-year follow-up study.
World J Otorhinolaryngol Head Neck Surg
March 2025
Objectives: The objective of this study was to study the various outcomes among coronavirus disease 2019 (COVID-19)-associated mucormycosis (CAM) in terms of morbidity and mortality.
Methods: A prospective study was done on 107 patients (60 male, 47 female) in the Department of Otolaryngology and Head and Neck Surgery, Government Medical College, Patiala, India, diagnosed with CAM from April 2021 to August 2021. The patients were managed both medically and surgically.
A Race Against Time: Rapidly Progressive Methicillin Resistant Pansinusitis with Vision Loss in an Immunocompetent Child.
Indian J Otolaryngol Head Neck Surg
February 2025
Department of Otorhinolaryngology, AIIMS Nagpur, Nagpur, India.
Acute sinusitis is a relatively common condition in pediatric patients. In most cases, it resolves completely with prompt medical management, but its rapid progression to severe orbital complications leading to restriction of extra-ocular movements and negative perception of light in the affected eye is rare and pose diagnostic and management challenges. The aggressive nature of acute rhinosinusitis requires urgent surgical intervention coupled with prompt medical management to prevent life threatening complications and outcomes.
View Article and Find Full Text PDFHerbal Medicine in Acute and Chronic Sinusitis; Still a Cinderella?
Curr Allergy Asthma Rep
March 2025
Department of Otorhinolaryngology, University of Crete School of Medicine, Heraklion, Crete, Greece.
Article Synopsis
- The review discusses the increasing relevance of herbal medicine as a potential treatment for both acute and chronic rhinosinusitis, particularly as conventional treatments face limitations.
- It highlights that while acute rhinosinusitis is common, its symptoms often overlap with other respiratory infections, complicating diagnosis and treatment, which usually involves symptomatic relief methods.
- Recent developments in herbal medicine, specifically through a method called phytoneering, show that certain herbal extracts can be effective for acute rhinosinusitis and may offer a promising alternative for chronic cases with fewer side effects.
Computer Integrated Dominant Epitopes Evoke Protective Immune Response Against Streptococcus pneumoniae.
Immunology
March 2025
ImmunoEngineering and Therapeutics Laboratory, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, India.
Streptococcus pneumoniae is a gram-positive bacterium responsible for various diseases like pneumonia, acute otitis media, sinusitis, meningitis and bacteraemia. These diseases cause a significant amount of morbidity and mortality. Although polysaccharide vaccines are available, the protection provided by these vaccines is serotype-dependent and not enough in sensitive populations like children and older people.
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