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Spot test with smartphone digital image analysis for determination of methadone in exhaled breath condensate.
Spectrochim Acta A Mol Biomol Spectrosc
December 2024
Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:
In this work, we explored the potential of the spot test combined with image analysis using smartphones as a rapid, simple, low-cost, and environmentally friendly method for identifying methadone concentration. Herein, a carbon-gold nanocomposite has been used to generate color variation at different concentrations of methadone. The data obtained from the digital image colorimetric method was compared with those from the UV-Vis spectroscopy as a standard technique.
View Article and Find Full Text PDFPreventive maintenance in urban public transport: the role of engine oil analysis.
Sci Rep
December 2024
Department of Power Engineering and Transportation, University of Life Sciences in Lublin, Gleboka 28, 20-612, Lublin, Poland.
Engine oil is a valuable source of information on the technical condition of the drive unit. Under the influence of many factors, including operating conditions, time, high temperature, and various types of contamination, the oil gradually degrades, which can result in serious engine damage. The subject of the article focuses on an attempt to answer the questions of how engine failure affects the degradation of engine oil and whether we can use this knowledge to detect potential problems in public transport vehicles at an early stage.
View Article and Find Full Text PDFNewborn Screening for Acid Sphingomyelinase Deficiency: Prevalence and Genotypic Findings in Italy.
Int J Neonatal Screen
December 2024
Division of Inherited Metabolic Diseases, Department of Women's and Children's Health, University Hospital of Padua, 35128 Padua, Italy.
Acid sphingomyelinase deficiency (ASMD) is a rare lysosomal storage disorder with a broad clinical spectrum. Early diagnosis and initiation of treatment are crucial for improving outcomes, yet the disease often goes undiagnosed due to its rarity and phenotypic heterogeneity. This study aims to evaluate the feasibility and disease incidence of newborn screening (NBS) for ASMD in Italy.
View Article and Find Full Text PDFA Reflective Terahertz Point Source Meta-Sensor with Asymmetric Meta-Atoms for High-Sensitivity Bio-Sensing.
Biosensors (Basel)
November 2024
Institute of Laser Engineering, Osaka University, Suita 565-0871, Osaka, Japan.
Biosensors operating in the terahertz (THz) region are gaining substantial interest in biomedical analysis due to their significant potential for high-sensitivity trace-amount solution detection. However, progress in compact, high-sensitivity chips and methods for simple, rapid and trace-level measurements is limited by the spatial resolution of THz waves and their strong absorption in polar solvents. In this work, a compact nonlinear optical crystal (NLOC)-based reflective THz biosensor with a few arrays of asymmetrical meta-atoms was developed.
View Article and Find Full Text PDFA case study of lethal neonatal CPT II deficiency: Novel insights from genetic analysis.
Mol Genet Metab Rep
December 2024
National Lung Hospital, 463 Hoang Hoa Tham, Ba Dinh, Hanoi, Viet Nam.
Introduction: Carnitine Palmitoyltransferase II (CPT II) deficiency encompasses a spectrum of disorders, with the lethal neonatal form (LNF) representing the rarest and most severe. While there are numerous gene variants that can cause CPT II deficiency, only 16 variants of these are known to be associated with LNF. This report presents the case of a neonatal male diagnosed with lethal CPT II deficiency, characterized by the presence of two heterogeneous variants.
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