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Decreased levels of ferritin, mild thrombocytosis, and increased erythropoietin are sequential events among frequent plateletpheresis donors: Implication for a ferritin screen.
Transfus Apher Sci
December 2022
Department of Medical Laboratory Science and Biotechnology, Chung Hwa University of Medical Technology, Tainan, Taiwan, ROC; Tainan Branch, Chinese Blood Donation Association, Tainan, Taiwan, ROC. Electronic address:
Background: It is generally recognized that repeat apheresis increases the risk for iron deficiency, thus may impact on the blood homeostasis. With regard to donor vigilance, we clarified the mid- to long-term effects of plateletapheresis by comparing the most frequent donors with the first-time ones in hematological and biochemical tests.
Methods: Levels of erythropoietin (EPO), hemoglobin (Hb) and ferritin were analyzed in double-unit (500 mL whole blood or 6 × 10 apheresis platelets) donations in three male cohorts, with identifiers of first-time whole-blood donors (n = 30), first-time platelet donors transited from maximal whole blood to apheresis (n = 30) and frequent donors subjected to extreme plateletpheresis (n = 90), respectively.
Analysis of Donor Safety in High Yield Plateletpheresis Procedures: An Experience from Tertiary Care Hospital in South India.
Indian J Hematol Blood Transfus
July 2020
Department of Biostatistics, National Institute of Mental Health and Neurosciences, Bengaluru, 560029 India.
The apheresis platelets are the preferred blood components for the thrombocytopenic hemato-oncology patients. The one of the important factors for post transfusion increment is the dose of the platelet product infused. The minimum platelet product yield is defined but the amount of maximum possible platelets collection from a single donor is not universally defined.
View Article and Find Full Text PDFSingle-donor platelet apheresis: observational comparison of the new Haemonetics Universal Platelet protocol with the previous Concentrated Single Donor Platelet protocol.
Blood Transfus
April 2014
Department of Immunohaematology and Transfusion Medicine, Bozen/Bolzano Hospital, Bolzano, Italy.
Background: The Haemonetics MCS(®)+ cell separator is a device dedicated to the collection of leucoreduced single-donor platelets. The new Universal Platelet protocol has been introduced to improve the efficiency of apheresis and increase flexibility in the collection of leucoreduced platelets in combination with red blood cells and plasma. In this study we compared its performance with that of the previous Concentrated Single Donor Platelet protocol.
View Article and Find Full Text PDFThe relationship of platelet yield, donor's characteristic and apheresis instruments in China.
Transfus Apher Sci
December 2013
Blood Center of Zhejiang Province, Hangzhou, Zhejiang, People's Republic of China.
Platelet yield was associated with donor's characteristic and property of apheresis instruments. Here, we have analyzed the relationship of platelet yield, physiologic parameters of donors for different apheresis instruments in China. Data were consecutively retrieved from plateletapheresis donors during March 1, 2007 and March 1, 2012.
View Article and Find Full Text PDFGrowth factor release from platelet concentrates: analytic quantification and characterization for clinical applications.
Vox Sang
August 2013
Dipartimento di Ricerca Traslazionale, S.O.S. Dipartimentale Trattamento Cellule Staminali per le Terapie Cellulari, Centro di Riferimento Oncologico, IRCCS, Aviano, PN, Italy.
Background And Objectives: Clinical use of plasma rich in growth factors requires biochemical product control. We aimed to measure and modulate concentrations of growth factors in solutions deriving from platelet apheresis or whole blood.
Materials And Methods: Growth factor concentrations were measured 5', 10', 20', 30', 60' after CaCl2 was added at 40°C to platelet-apheresis products (n = 39) or after 60' in platelet concentrates from whole blood (n = 13).
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