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Cord blood platelet-rich plasma: proteomics analysis for ophthalmic applications.
Clin Proteomics
January 2025
Ophthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli, 1, 00168, Rome, Italy.
Our objective is to determine the protein and complements constituents of Cord blood Platelet-rich plasma (CB-PRP), based on the hypothesis that it contains beneficial components capable of arresting or potentially decelerating the advancement of atrophic age-related macular degeneration (dry-AMD), with the support of radiomics. Two distinct pools of CB-PRP were assessed, each pool obtained from a total of 15 umbilical cord-blood donors. One aliquot of each pool respectively was subjected to proteomic analysis in order to enhance the significance of our findings, by identifying proteins that are shared between the two sample pools and gaining insights into the pathways they are associated with.
View Article and Find Full Text PDFBaolier Capsule's Secret Weapon: Piperine Boosts Cholesterol Excretion to Combat Atherosclerosis.
Drug Des Devel Ther
January 2025
Department of Cardiology, The Seventh Affiliated Hospital of Southern Medical University, Southern Medical University, Foshan, 528244, People's Republic of China.
Purpose: The Baolier capsule (BLEC) is a proprietary Mongolian medicine administered for treating hypercholesterolemia and atherosclerosis (AS). However, the therapeutic effects, primary bioactive ingredients, and potential mechanisms underlying hypercholesterolemia and AS remain unclear. This study aimed to investigate the pharmacological effects, principal active ingredients, and mechanisms of BLEC against hypercholesterolemia and AS.
View Article and Find Full Text PDFHow predictive-forward-collision-warning reduces the collision risk of leading vehicle driver.
Accid Anal Prev
December 2024
College of Metropolitan Transportation, Beijing University of Technology, Beijing, China.
Mixed platoon with a human-driven leading vehicle may be a transition mode prior to the widespread adoption of fully autonomous platoon. Enhancing the driving safety of the leading vehicle driver is crucial for improving the overall operational safety of the mixed platoon. Predictive-Forward-Collision-Warning (PFCW), an emerging technology in transportation, holds promise in mitigating collision risks for drivers by presenting traffic information beyond their immediate visual range.
View Article and Find Full Text PDFProgress in photocatalytic degradation of industrial organic dye by utilising the silver doped titanium dioxide nanocomposite.
Heliyon
December 2024
Mechanical Engineering Department, Faculty of Engineering, Brawijaya University, MT Haryono167, Malang, 65145, Indonesia.
Industrial organic dyes represent a significant portion of pollutants discharged into the environment, particularly by the textile industry. These compounds pose serious threats to living organisms due to their high toxicity. Various techniques have been explored for the degradation of organic dyes, among which heterogeneous photocatalysis utilising titanium dioxide (TiO) stands out as a promising technology.
View Article and Find Full Text PDFMaximizing insights from longitudinal epigenetic age data: simulations, applications, and practical guidance.
Clin Epigenetics
December 2024
School of Mathematical and Statistical Sciences, University of Galway, Galway, Ireland.
Background: Epigenetic age (EA) is an age estimate, developed using DNA methylation (DNAm) states of selected CpG sites across the genome. Although EA and chronological age are highly correlated, EA may not increase uniformly with time. Departures, known as epigenetic age acceleration (EAA), are common and have been linked to various traits and future disease risk.
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