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The potential impact of optimal blood pressure treatment intensity to reduce disparities in dementia between Black and White individuals.
J Alzheimers Dis
January 2025
Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Background: Black adults have higher dementia risk than White adults. Whether tighter population-level blood pressure (BP) control reduces this disparity is unknown.
Objective: Estimate the impact of optimal BP treatment intensity on racial disparities in dementia.
Endonuclease G promotes hepatic mitochondrial respiration by selectively increasing mitochondrial tRNA production.
Proc Natl Acad Sci U S A
January 2025
Laboratory of Obesity and Aging Research, Cardiovascular Branch, National Heart Lung and Blood Institute, NIH, Bethesda, MD 20892.
Mitochondrial endonuclease G (EndoG) contributes to chromosomal degradation when it is released from mitochondria during apoptosis. It is presumed to also have a mitochondrial function because EndoG deficiency causes mitochondrial dysfunction. However, the mechanism by which EndoG regulates mitochondrial function is not known.
View Article and Find Full Text PDFAssociation of early-life trauma with gestational diabetes and hypertensive disorders of pregnancy.
Epidemiology
December 2024
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC.
Background: Early-life trauma (before age 18) is hypothesized to increase risk for adverse pregnancy outcomes through stress pathways, yet epidemiologic findings are mixed.
Methods: Sister Study participants (U.S.
Exploring salinity induced adaptations in marine diatoms using advanced photonic techniques.
Sci Rep
December 2024
Center for Photonic Science and Engineering, Skolkovo Institute of Science and Technology, 30 Bolshoy Boulevard, bld. 1, Moscow, 121205, Russia.
Photonic-based methods are crucial in biology and medicine due to their non-invasive nature, allowing remote measurements without affecting biological specimens. The study of diatoms using advanced photonic methods remains a relatively underexplored area, presenting significant opportunities for pioneering discoveries. This research provides a comprehensive analysis of marine diatoms, specifically Nitzschia sp.
View Article and Find Full Text PDFRecurrent Acute Myocardial Infarction in a Patient with Severe Coronary Artery Ectasia Followed Up for 10 Years: Implications of Anticoagulant Therapy.
Am J Case Rep
December 2024
Department of Cardiology, Tianjin Medical University General Hospital, Tianjin, China.
BACKGROUND Coronary artery ectasia (CAE) represents not only an anatomical variant but also a clinical constellation of coronary artery disease associated with acute coronary syndrome (ACS). There is no consensus on the antithrombotic treatment for patients with CEA. CASE REPORT A 34-year-old man with severe diffuse dilatation of the left main artery and left circumflex (LCX) proximal segment confirmed by coronary angiography (CAG) developed 2 acute myocardial infarctions (AMIs), due to occlusion of a dilated LCX segment with thrombus shadows, within a 9-year interval.
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