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Obstacle contrast modulates gait behavior in younger and older adults.
Optom Vis Sci
January 2025
Indiana University School of Optometry, Bloomington, Indiana.
Purpose: This study investigated how obstacle contrast altered gait behavior of healthy younger and older adults.
Methods: Twenty normally sighted adults, 11 older (mean [standard deviation] age, 68.1 [5.
Manganese exposure induces parkinsonism-like symptoms by Serpina3n-TFEB-v/p-ATPase signaling mediated lysosomal dysfunction.
Cell Biol Toxicol
January 2025
Department of Environmental Medicine, School of Medicine, Chongqing University, Chongqing, China.
Manganese (Mn) is a neurotoxin that has been etiologically linked to the development of neurodegenerative diseases in the case of overexposure. It is widely accepted that overexposure to Mn leads to manganism, which has clinical symptoms similar to Parkinson's disease (PD), and is referred to as parkinsonism. Astrocytes have been reported to scavenge and degrade extracellular α-synuclein (α-Syn) in the brain.
View Article and Find Full Text PDFIdentification of the Skip Phenomenon Among Patients With Infective Endocarditis: A Retrospective Review.
Open Forum Infect Dis
January 2025
Division of Public Health, Infectious Disease, and Occupational Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
The skip phenomenon (SP) is a pattern where blood cultures are intermittently positive before final clearance. We report that one-third of patients with infective endocarditis experienced the SP. Patients with the SP experienced both a longer duration of bacteremia and hospital stay, with a higher 1-year mortality rate.
View Article and Find Full Text PDF'They went for the test together but came back separately': a constructivist grounded theory perspective on male engagement in antenatal HIV testing in Bamenda, Cameroon.
BMC Pregnancy Childbirth
January 2025
Department of Disease Control, London School of Hygiene and Tropical Medicine, London, UK.
Introduction: Male engagement in HIV testing during pregnancy significantly contributes towards the prevention of maternal seroconversion and paediatric HIV acquisition. Despite this, men especially the male partners of pregnant women have been consistently missing in the HIV prevention cascade. The factors accounting for sub-optimal levels in male engagement intersect but reasons for this are poorly understood.
View Article and Find Full Text PDFPharmacodynamics and pharmacokinetics of rocuronium in sevoflurane-anesthetized Thoroughbred horses.
Vet Anaesth Analg
December 2024
Equine Research Institute, Japan Racing Association, Shimotsuke, Japan.
Objective: To investigate the pharmacodynamics and pharmacokinetics of rocuronium administered by bolus injection to sevoflurane-anesthetized horses.
Study Design: Prospective, experimental, crossover study.
Animals: Five healthy adult Thoroughbred horses (body mass 368-470 kg, three females and two males).
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