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Heart failure with preserved ejection fraction in atrial functional mitral regurgitation - Insight from the REVEAL-AFMR.
Int J Cardiol
January 2025
Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, Japan. Electronic address:
Article Synopsis
- HFpEF is commonly found in patients with moderate AFMR, significantly impacting clinical outcomes, leading to higher mortality and hospitalization rates.
- Patients with HFpEF-AFMR were generally older and faced more severe symptoms, including a higher prevalence of severe tricuspid regurgitation.
- Interventions, such as combined mitral and tricuspid valve procedures or rhythm control therapy, improved clinical outcomes compared to isolated treatments.
Nanoscale reference and test materials for the validation of characterization methods for engineered nanomaterials - current state, limitations, and needs.
Anal Bioanal Chem
January 2025
Division Biophotonics, Federal Institute for Materials Research and Testing (BAM), Richard-Willstaetter-Str. 11, 12489, Berlin, Germany.
The rational design of engineered nanomaterials (NMs) with improved functionality and their increasing industrial application requires reliable, validated, and ultimately standardized characterization methods for their application-relevant, physicochemical key properties such as size, size distribution, shape, or surface chemistry. This calls for nanoscale (certified) reference materials (CRMs; RMs) and well-characterized reference test materials (RTMs) termed also quality control (QC) samples, assessed, e.g.
View Article and Find Full Text PDFThe role of circulating tumor DNA in melanomas of the uveal tract.
Front Immunol
December 2024
Department of Oncology, Medical Sciences Division, University of Oxford, Oxford, United Kingdom.
Melanoma of the uveal tract or uveal melanoma (UM) originates from melanocytes of the eye and is the most common intraocular malignancy in adults. Despite considerable advances in diagnostic procedures and treatments, prognosis remains poor in those with advanced disease. Accordingly, although current treatments have an excellent local disease control rate, approximately 50% of patients develop metastatic relapse within 10 years.
View Article and Find Full Text PDFMagnesium (Mg) and Neurodegeneration: A Comprehensive Overview of Studies on Mg Levels in Biological Specimens in Humans Affected Some Neurodegenerative Disorders with an Update on Therapy and Clinical Trials Supplemented with Selected Animal Studies.
Int J Mol Sci
November 2024
Department of Pathomorphology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 3 Maja St. 13, 41-800 Zabrze, Poland.
Article Synopsis
- - Neurodegenerative diseases, like Alzheimer's and Parkinson's, lead to neuron loss and significantly impact many lives, prompting the search for new therapies beyond current medications.
- - Magnesium (Mg) is an essential mineral important for central nervous system health, but its specific role in human neurodegenerative diseases is not well understood.
- - This review explores the connection between Mg levels and neurodegenerative disorders by analyzing biological samples from patients and animal model studies, suggesting that Mg may have neuroprotective properties; however, further research is needed for clarity on its therapeutic use.
Prognostic Significance of Recurrence and Timing of Recurrence on Survival Among Patients with Early-Stage Hepatocellular Carcinoma in U.S. Clinical Practice.
Ann Surg Oncol
February 2025
Genentech, South San Francisco, CA, USA.
Background: Many patients with hepatocellular carcinoma (HCC) experience recurrence after curative-intent resection or ablation, with a poor prognosis. Real-world patterns of recurrence and the prognostic significance of early recurrence in U.S.
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