New technologies in both combinatorial chemistry and combinatorial biology promise to unlock new opportunities for drug discovery and lead optimisation. Using such genome-based technologies to measure the dynamic properties of pharmacological systems, pharmacogenomics can now provide an objective measure of a drug's biological efficacy, including its potential adverse effects.
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Influence of different factors (duration of disease, gender, education, patients' history, job and age) in metformin response in type 2 diabetes mellitus patient.
Wiad Lek
September 2024
DEPARTMENT OF MICROBIOLOGY, FACULTY OF MEDICINE, UNIVERSITY OF KUFA, NAJAF, IRAQ
Objective: Aim: This study aims to evaluate how various factors affect various aspects of glycemic control in individuals with type 2 diabetes who are undergoing metformin treatment.
Patients And Methods: Materials and Methods: A cross-sectional study involved 150 participants who met specific criteria, including being aged between 30 and 70, having a type 2 diabetes diagnosis, and using 1000 mg of metformin as the monotherapy for at least three months. Collected data encompassed various measures, such as levels of glycated hemoglobin (HbA1c), fasting blood glucose concentrations, fasting serum insulin levels, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), and insulin sensitivity.
Effect of pharmacogenomic testing on the clinical treatment of patients with depressive disorder: A randomized clinical trial.
J Affect Disord
August 2024
Department of Psychiatry, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. Electronic address:
Background: Pharmacotherapy is one of the primary treatment modalities for depression. However, there is considerable variability in the individual response to antidepressant medications. Personalized medicine guided by pharmacogenomic testing may hold promise in addressing this issue.
View Article and Find Full Text PDFAbemaciclib pharmacology and interactions in the treatment of HR+/HER2- breast cancer: a critical review.
Ther Adv Drug Saf
April 2024
Faculty of Medicine and Surgery, Kore University of Enna, Piazza dell'Università, Enna 94100, Italy.
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View Article and Find Full Text PDFNinety-eight semesters of cytochrome P450 enzymes and related topics-What have I taught and learned?
J Biol Chem
February 2024
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. Electronic address:
This Reflection article begins with my family background and traces my career through elementary and high school, followed by time at the University of Illinois, Vanderbilt University, the University of Michigan, and then for 98 semesters as a Vanderbilt University faculty member. My research career has dealt with aspects of cytochrome P450 enzymes, and the basic biochemistry has had applications in fields as diverse as drug metabolism, toxicology, medicinal chemistry, pharmacogenetics, biological engineering, and bioremediation. I am grateful for the opportunity to work with the Journal of Biological Chemistry not only as an author but also for 34 years as an Editorial Board Member, Associate Editor, Deputy Editor, and interim Editor-in-Chief.
View Article and Find Full Text PDFExploring blood metabolites and thyroid disorders: a bidirectional mendelian randomization study.
Front Endocrinol (Lausanne)
October 2023
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Background: Human blood metabolites have demonstrated close associations with thyroid disorders in observational studies. However, it's essential to determine whether these correlations imply causation. Mendelian Randomization (MR) offers a promising approach to investigate these patterns.
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