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ACG Case Rep J
January 2025
Department of Medical Oncology, University of Kansas Medical Center, Westwood, KS.
Cytomegalovirus colitis most commonly affects immunocompromised patients, although it is a rare cause of gastrointestinal bleeding in immunocompetent patients. Older age, chronic disease, and critical illness are also important risk factors and may lead providers to consider the diagnosis in otherwise immunocompetent patients. Endoscopic presentation is variable and does not significantly influence outcomes.
View Article and Find Full Text PDFCurr Med Imaging
January 2025
Department of Nuclear Medicine, Hangzhou Cancer Hospital, Hangzhou 310002, China.
Background: Cytomegalovirus (CMV) infection is common in the digestive and central nervous systems and can infect the entire digestive tract from the mouth to the rectum. In immunocompromised patients, CMV infection is prone to develop into CMV disease, especially in Acquired Immune Deficiency Syndrome (AIDS) patients. Severe cases may accelerate the progression of AIDS patients and form systemic CMV infection.
View Article and Find Full Text PDFCureus
December 2024
Infectious Diseases, Hospital Garcia de Orta, Lisbon, PRT.
Extra-cavitary primary effusion lymphoma (PEL), often associated with human herpes virus 8 (HHV8) infection, represents a rare and aggressive form of non-Hodgkin lymphoma, which is predominantly found in individuals with severe immunosuppression. As an acquired immunodeficiency syndrome (AIDS)-associated lymphoma, PEL typically manifests in the context of advanced human immunodeficiency virus (HIV) infection, requiring tailored therapeutic approaches to manage both the lymphoma and underlying immunodeficiency. A 53-year-old male patient from Cape Verde presented with a three-day history of fever, night sweats, right iliac fossa pain, hematochezia, and an unintentional weight loss of five kilograms over the previous two months.
View Article and Find Full Text PDFACG Case Rep J
December 2024
Gastroenterology Department, Henry Ford Hospital, Detroit, MI.
Alzheimers Dement
January 2025
Banner Alzheimer's Institute, Phoenix, Arizona, USA.
Introduction: While there may be microbial contributions to Alzheimer's disease (AD), findings have been inconclusive. We recently reported an AD-associated CD83(+) microglia subtype associated with increased immunoglobulin G4 (IgG4) in the transverse colon (TC).
Methods: We used immunohistochemistry (IHC), IgG4 repertoire profiling, and brain organoid experiments to explore this association.
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