Traditionally, biomedical or clinical outcomes have been the main foci of attention in the care of the chronically ill, but efforts are now being made to measure other outcomes that derive from patient-reported experiences. In diabetes treatment and care, the situation has become particularly complex as rigid glycaemic control, now believed to be correlated with a reduced incidence of long-term complications, may not be compatible with a high level of quality of life. The acceptance of a linear relationship between levels of glycaemic control and relative risk of complications does not address the fact that quality of life has not been included as a variable in these analyses. If a reduction from 11 to 9.9% leads to a lower risk of retinopathy progression of 6.67 cases per 100 patient years, a reduction from 8 to 7.2% decreases risk by only 0.95 cases per 100 patient years. In the latter case, it may be asked whether this relatively small reduction is worth a lifetime deterioration in quality of life. We suggest that clinicians in their treatment of diabetic patients must give as much attention to quality of life as to biological outcomes and complications. An important question remaining is: How good are our tools for measuring quality of life?
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ACS Nano
January 2025
State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing 210023, China.
Under a changing climate, enhancing the drought resilience of crops is critical to maintaining agricultural production and reducing food insecurity. Here, we demonstrate that seed priming with amorphous silica (SiO) nanoparticles (NPs) (20 mg/L) accelerated seed germination speed, increased seedlings vigor, and promoted seedling growth of rice under polyethylene glycol (PEG)-mimicking drought conditions. An orthogonal approach was used to uncover the mechanisms of accelerated seed germination and enhanced drought tolerance, including electron paramagnetic resonance, Fourier transform infrared spectroscopy (FTIR), metabolomics, and transcriptomics.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
School of Chemical Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.
Photobiomodulation (PBM) is considered an effective and safe therapeutic modality in supporting the treatment of complications from a global pandemic-diabetes. In this study, PBM therapy is investigated to accelerate wound healing in diabetic mice (DM), under the combined biological effects of red light from a red organic light-emitting diode (ROLED) and near-infrared (NIR) light from an NIR conversion film (NCF) with dispersed CuInS/ZnS quantum dots (QDs). The QD concentration and the NCF structure were optimized to maximize the optical properties and mechanical stability.
View Article and Find Full Text PDFValue Health Reg Issues
January 2025
Novartis Singapore Pte Ltd, Singapore. Electronic address:
Objectives: This analysis evaluated the cost-effectiveness of inclisiran plus standard of care (SoC; comprising statins, ezetimibe, and fenofibrate) in primary hypercholesterolemia or mixed dyslipidemia from a Singapore healthcare system perspective. Inclisiran + SoC was separately compared with SoC, alirocumab + SoC, and evolocumab + SoC.
Methods: A lifetime Markov model in the United Kingdom (UK) was adapted to the Singapore setting.
Clin Breast Cancer
December 2024
Department of Oncology, Princess Margaret Hospital, Kowloon West Cluster, Hospital Authority, Hong Kong S.A.R., China. Electronic address:
J Voice
January 2025
Nitte Deemed to be University, Nitte Institute of Speech and Hearing, Mangalore, Karnataka, India. Electronic address:
Objectives: To compare certain acoustic, aerodynamic, and perceptual parameters before and after an hour-long class to analyze vocal loading characteristics in female Bharatanatyam dance teachers.
Study Design: Prospective study.
Method: The study included 52 female Bharatanatyam dance teachers aged 19 to 40years.
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