AI Article Synopsis
- The article discusses updated guidelines for choosing the right antimicrobial agents and dosages in treating severe sepsis to avoid septic shock.
- It covers new insights into how sepsis and septic shock develop.
- Additionally, it examines factors like beta-lactam antibacterial effectiveness, the role of antibiotics in releasing endotoxins, and how drug absorption and effects impact treatment strategies for critically ill patients in intensive care.
Article Abstract
This article reviews the new criteria for selecting the proper antimicrobial agent and dosage regimen for standard treatment of severe sepsis, with the intention of preventing septic shock. After introducing new concepts on the pathogenesis of sepsis and septic shock, the authors analyze the parameters of betalactam antibacterial activity, the antibiotic-induced release of bacterial endotoxin and the interrelationships between pharmacokinetics and pharmacodynamics of antibiotics in the search for an optimum dosage regimen of antimicrobial mono- or polytherapy for severely ill septic patients admitted to the intensive care unit.
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| http://dx.doi.org/10.1179/joc.1998.10.6.427 | DOI Listing |
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