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[Fish odor syndrome: A socially disabling disorder].
Rev Med Interne
March 2022
Service de médecine interne, CHRU de Tours, Tours, France; Université de Tours, Tours, France; Inserm U1253, Tours, France. Electronic address:
Introduction: Fish odor syndrome (FOS) is a rare metabolic disorder that manifests as "rotten fish" body odor and is caused by the excretion of trimethylamine (TMA) in body fluids. This disease can have a negative impact on the social life of affected patients.
Case Reports: We report the case of two female patients complaining about unpleasant body odor.
Gut-Brain Axis Cross-Talk and Limbic Disorders as Biological Basis of Secondary TMAU.
J Pers Med
January 2021
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Division of Medical Biotechnologies and Preventive Medicine, University of Messina, 98125 Messina, Italy.
: Trimethylaminuria (TMAU) is a rare metabolic syndrome characterized by the accumulation and the excretion of trimethylamine (TMA), a volatile diet compound produced by gut microbiota. Gut microbiota alterations are mainly involved in the secondary TMAU, whose patients show also different psychiatric conditions. We hypothesized that the biological activity of several molecules acting as intermediate in TMA metabolic reaction might be at the basis of TMAU psychiatric comorbidities.
View Article and Find Full Text PDFLe Carbone prevents liver damage in non-alcoholic steatohepatitis-hepatocellular carcinoma mouse model via AMPKα-SIRT1 signaling pathway activation.
Heliyon
January 2021
Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata 956-8603, Japan.
Article Synopsis
- Le Carbone (LC) is a dietary supplement made from activated charcoal and is investigated for its potential to protect against liver damage in a specific mouse model of non-alcoholic steatohepatitis-hepatocellular carcinoma (NASH-HCC).
- The study involved administering LC to NASH mice and analyzing its effects on liver health, showing improvements in histopathology and liver enzyme levels.
- LC treatment was found to restore key metabolic protein expressions that were depressed in NASH mice, suggesting it may work by enhancing the AMPK-SIRT1 signaling pathway to mitigate liver damage.
Background: Trimethylaminuria (TMAU) (OMIM #602079) is a rare inherited metabolic condition. TMAU is associated with decreased hepatic trimethylamine N-oxidation, which leads to an excess of the volatile trimethylamine (TMA) instead of substrate conversion to trimethylamine N-oxide (TMAO). TMA is a tertiary amine derived from the enterobacterial metabolism of precursors such as choline and phosphatidylcholine present in the diet, and is also a bacterial metabolite of TMAO, a normal constituent of saltwater fish.
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