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The conserved wobble uridine tRNA thiolase Ctu1 is required for angiogenesis and embryonic development.
PLoS One
December 2024
School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Cytosolic thiouridylase is a conserved cytoplasmic tRNA thiolase composed of two different subunits, CTU1 and CTU2. CTU2 serves as a scaffold protein, while CTU1 catalyzes the 2-thiolation at the 34th wobble uridine of the anticodon loop. tRNAGlnUUG, tRNAGluUUC, and tRNALysUUU are the tRNA substrates that are modified with a thiol group at the C2 positions (s2) by CTU1, and also with a methoxycarbonylmethyl group at the C5 positions (mcm5) by Elongator and ALKBH8.
View Article and Find Full Text PDFComparative in situ characterization of erythroid cells found throughout the developing tongue tissue, circulation, and liver of fetal mice.
Ann Anat
February 2025
Department of Anatomy, School of Life Dentistry at Tokyo, The Nippon Dental University, Tokyo, Japan. Electronic address:
Background: Erythroid cells contribute to embryonic organ development and adult tissue repair supplying oxygen to tissues. During mouse development, the primitive erythroid cells produced in the extraembryonic blood islands of the yolk sac begin to circulate as immature and nucleated erythroblasts with the onset of cardiac contractions around embryonic day 9.5 (E9.
View Article and Find Full Text PDFStatin-treated RBC dynamics in a microfluidic porous-like network.
Microvasc Res
March 2025
FluME, Department of Mechanical Engineering, University College London, London, UK; UCL Hawkes Institute, University College London, London, UK. Electronic address:
The impact of therapeutic interventions on red blood cell (RBC) deformability and microscale transport is investigated, using statins as an exemplar. Human RBCs were treated in vitro with two commonly prescribed statins, atorvastatin and rosuvastatin, at clinically relevant concentrations. Changes in RBC deformability were quantified using a microfluidic-based ektacytometer and expressed in terms of the elongation index.
View Article and Find Full Text PDFDeposit of Red Blood Cells at low concentrations in evaporating droplets is dominated by a central edge growth.
J Colloid Interface Sci
February 2025
Department of Experimental Physics & Center for Biophysics, Saarland University, Saarbruecken, D-66123, Germany. Electronic address:
Evaporation of blood droplets and diluted blood samples is a topic of intensive research, as it is considered a potential low-cost diagnostic tool. So far, samples with a volume fraction down to a few percent of red blood cells have been studied, and these were reportedly dominated by a "coffee-ring" deposit. In this study, samples with lower volume fractions were used to investigate the growth of the evaporative deposit from sessile droplets in more detail.
View Article and Find Full Text PDFGene expression profiling in Venous thromboembolism: Insights from publicly available datasets.
Comput Biol Chem
December 2024
Defence Institute of Physiology and Allied Sciences (DIPAS), Defence Research and Development Organization (DRDO), Lucknow Road, Timarpur, Delhi 110054, India. Electronic address:
Article Synopsis
- VTE is a major cardiovascular disease linked to high mobility and mortality rates, yet its genetic mechanisms are not fully understood; this study aims to identify key genes and pathways involved in its progression.
- Researchers analyzed differential gene expression from two datasets, discovering 19 up-regulated and 134 down-regulated genes in VTE patients compared to healthy controls, using various bioinformatics tools.
- The study identified significant pathways related to inflammation and coagulation in VTE patients and highlights key hub genes that could aid in developing new diagnostic and therapeutic strategies for the disease.
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