The structure-activity relationship of a series of non-thiol CaaX analogs, which are inhibitors of farnesyltransferase, is described. These inhibitors contain a substituted phenyl group at the N terminus, which may occupy a novel binding domain on the Ras protein.
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| http://dx.doi.org/10.1016/s0960-894x(98)00586-1 | DOI Listing |
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