Prodrugs bioreductively activated to bleomycin analogues are reported. The production of hydroxyl radicals in the presence of FE(II) and dioxygen by both the prodrugs and the activated products are determined and their in vitro cytotoxicity measured.
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| http://dx.doi.org/10.1016/s0960-894x(98)00467-3 | DOI Listing |
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