1 (L-374,087) is a potent, selective, efficacious, and orally bioavailable thrombin inhibitor that contains a core 3-amino-2-pyridinone moiety. Replacement of the C6 pyridinone methyl group of 1 by a propyl group gave 5 (L-375,052), which retained all the excellent properties of 1, and also yielded higher plasma levels after oral dosing in dogs and rats.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0960-894x(98)00297-2 | DOI Listing |
Publication Analysis
Top Keywords
thrombin inhibitor
8
modification pyridinone
4
pyridinone core
4
core thrombin
4
inhibitor l-374087
4
l-374087 enhancing
4
enhancing oral
4
oral absorption
4
absorption l-374087
4
l-374087 potent
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!