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Heteroatom-substitution as a strategy for increasing the potency of competitive NMDA antagonists. | LitMetric

Heteroatom-substitution as a strategy for increasing the potency of competitive NMDA antagonists.

Bioorg Med Chem Lett

Lilly Research Laboratories, Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA.

Published: February 1998

We report the synthesis and characterization of compounds that are competitive NMDA receptor antagonists. Significant increases in affinity and potency were obtained by incorporation of a heteroatom into the substructure of the tetrazole-substituted amino acid LY233053.

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Source
http://dx.doi.org/10.1016/s0960-894x(98)00038-9DOI Listing

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