Role of zinc in blockade of excitotoxic action of quinolinic acid by picolinic acid.

Amino Acids

Department of Pharmacology and Toxicology, Queen's University, Kingston, Ontario, Canada.

Published: January 1999

This study examined whether picolinic acid (PIC) inhibits quinolinic acid (QUIN)-induced excitotoxicity through zinc chelation. Injection of QUIN into the nucleus basalis magnocellularis significantly depleted cortical choline acetyltransferase activity 7 days post injection and PIC inhibited this response. Zinc augmented the QUIN- but not NMDA-induced response. When PIC was co-administered with zinc, PIC failed to attenuate the QUIN-induced response. The inhibition of QUIN-induced cholinergic toxicity by PIC may involve chelation of zinc.

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http://dx.doi.org/10.1007/BF01345272DOI Listing

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