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Assessing the real-world effectiveness of 8 major metastatic breast cancer drugs using target trial emulation.
Eur J Cancer
December 2024
UMR CNRS 5558 LBBE, Claude Bernard Lyon 1 University, Villeurbanne, France; Prevention & Public Health Department, Centre Léon Bérard, Lyon, France.
Background: Demonstration of trial emulation ability to benchmark randomised controlled trials (RCTs) from real-world data (RWD) is required to increase confidence in the use of routinely collected data for decision making in oncology.
Methods: To assess the frequency with which emulation findings align with RCTs regarding effect size on overall survival (OS) in metastatic breast cancer (MBC), 8 of 13 pre-selected pivotal RCTs in MBC were emulated using data from 32,598 patients enrolled in the French ESME-MBC cohort between January 1, 2008 and December 31, 2021. Adjustment methods and confounders were selected a priori for each emulation; stabilized weight was the reference method to mitigate confounding.
Patients' Satisfaction after the Treatment of Moderate Sleep Apnea and Nocturnal Bruxism with Botox or/and Thermoformed Occlusal Splints: A Pilot Study.
J Pers Med
September 2024
Faculty of Dental Medicine, "George Emil Palade" University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 38 Gh. Marinescu Street, 540142 Targu Mures, Romania.
: Sleep apnea and nocturnal bruxism belong to sleep disorders that can affect the quality of life. The aim of this study was to investigate the effects on patients with moderate sleep apnea and nocturnal bruxism of Botox injection as monotherapy or associated with wearing thermoformed occlusal splints and to determine the patients' satisfaction degree after the applied treatments. : The selected patients for study were divided into two groups: in the first group, the patients ( = 18) treatment consisted of injecting Botox (Allergan) into the masseter muscle as monotherapy; in the second group, the patients ( = 18) benefited from associated therapy, Botox injections in masseter muscle, and the wear of thermoformed occlusal splints.
View Article and Find Full Text PDFThe Stresses and Deformations in the Abfraction Lesions of the Lower Premolars Studied by the Finite Element Analyses: Case Report and Review of Literature.
Diagnostics (Basel)
April 2024
Faculty of Dental Medicine, "George Emil Palade" University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 38 Gh. Marinescu Street, 540142 Targu Mures, Romania.
Article Synopsis
- The study aimed to explore how hard dental structures in teeth with abfraction lesions react to different types of occlusal loads.
- A 65-year-old patient experiencing pain in her jaw and lower right premolars underwent a 3D imaging examination, followed by a finite element analysis to assess structural integrity.
- Results showed that the cervical third of premolars is especially vulnerable to inclined occlusal loads, which caused significantly higher stress than axial loads, highlighting the importance of FEA in dental treatment planning.
Single-center experience of congenital disorders of glycosylation syndrome screening in Tunisia: A retrospective study over a 15-year period (2007-2021).
Arch Pediatr
February 2024
University of Tunis El Manar, Faculty of Medicine of Tunis, Tunis, Tunisia; Rabta Hospital, Laboratory of Biochemistry, LR99ES11 Tunis, Tunisia. Electronic address:
Background: We report the results gathered over 15 years of screening for congenital disorders of glycosylation syndrome (CDGS) in Tunisia according to clinical and biochemical characteristics.
Methods: Our laboratory received 1055 analysis requests from various departments and hospitals, for children with a clinical suspicion of CDGS. The screening was carried out through separation of transferrin isoforms by capillary zone electrophoresis.
Kawarabi: Administrative Structuring of a Multicenter Research Collaborative to Study Kawasaki Disease in the Arab Countries.
World J Pediatr Congenit Heart Surg
March 2024
Division of Pediatric Cardiology, Department of Pediatrics, Icahn School of Medicine, Mount Sinai Kravis Children's Hospital, New York, NY, USA.
Article Synopsis
- - Kawasaki disease (KD) is the leading cause of acquired heart disease in children from developed countries, necessitating detailed studies within Arab nations to enhance diagnosis and care.
- - Kawarabi is a collaborative initiative involving North American and Arab experts aimed at improving knowledge and management of KD and similar conditions, primarily initiated during the COVID-19 pandemic's emergence of multisystem inflammatory syndrome in children.
- - Founded in 2021, Kawarabi has identified gaps in awareness and resources concerning KD in Arab countries, and it has organized educational webinars and meetings to promote better understanding of the disease and its long-term outcomes.
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