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Priority Clinical Actions for Outpatient Management of Nonhospitalized Traumatic Brain Injury.
J Neurotrauma
January 2025
Zuckerberg San Francisco General Hosptial and Trauma Center, University of California, San Francisco, San Francisco, California, USA.
Outpatient care following nonhospitalized traumatic brain injury (TBI) is variable, and often sparse. The National Academies of Sciences, Engineering, and Medicine's 2022 report on highlighted the need to improve the consistency and quality of TBI care in the community. In response, the present study aimed to identify existing evidence-based guidance and specific clinical actions over the days to months following nonhospitalized TBI that should be prioritized for implementation in primary care.
View Article and Find Full Text PDFFrom Genes to Metabolites: HSP90B1's Role in Alzheimer's Disease and Potential for Therapeutic Intervention.
Neuromolecular Med
January 2025
Department of Neurology, Second Affiliated Hospital of Army Medical University (Xinqiao Hospital), Chongqing, China.
Alzheimer's disease (AD) is a prototypical neurodegenerative disorder, predominantly affecting individuals in the presenile and elderly populations, with an etiology that remains elusive. This investigation aimed to elucidate the alterations in anoikis-related genes (ARGs) in the AD brain, thereby expanding the repertoire of biomarkers for the disease. Using publically available gene expression data for the hippocampus from both healthy and AD subjects, differentially expressed genes (DEGs) were identified.
View Article and Find Full Text PDFEnvironmental bioremediation of pharmaceutical residues: microbial processes and technological innovations: a review.
Bioprocess Biosyst Eng
January 2025
Faculty of Civil Engineering & Built Environment, Universiti Tun Hussein Onn Malaysia, Batu Pahat, 86400, Parit Raja, Johor, Malaysia.
The ubiquitous presence of pharmaceuticals and personal care products (PPCPs) in the environment has become a significant concern due to their persistence, bioaccumulation potential in biota, and diverse implications for human health and wildlife. This review provides an overview of the current state-of-the-art in environmental bioremediation techniques for reducing pharmaceutical residues, with a special emphasis on microbial physiological aspects. Numerous microorganisms, including algae, bacteria or fungi, can biodegrade various pharmaceutical compounds such as antibiotics, analgesics and beta-blockers.
View Article and Find Full Text PDFDirections for improving the financial support of forensic expert forensic activity in Ukraine with account of positive foreign experience.
Forensic Sci Int Synerg
December 2024
Department of Political Sciences and Law, Kyiv National University of Construction and Architecture, 31, Povitroflotsky Avenue, Kyiv, 03037, Ukraine.
The relevance of the issues studied in this article is due to the need to form an efficiently functioning system of regulating forensic expert activity in general and its individual components, in particular, financial support, taking into account positive foreign experience. The author proposes to introduce separate budget programmes for state specialised institutions of each state agency, which will help to resolve the issues of proper funding and justification of expenditures, and will serve as an anti-corruption factor. Attention is focused on the need to develop a unified methodological approach to calculating the number of forensic examinations.
View Article and Find Full Text PDFInvestigation of oligomeric proanthocyanidins extracted from Rhodiolae Crenulatae Radix et Rhizomes using deep eutectic solvents and identified via data-dependent acquisition mass-spectroscopy.
J Pharm Anal
November 2024
National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
In this study, 34 deep eutectic solvents (DESs) were successfully prepared for the extraction of proanthocyanidin from Rhodiolae Crenulatae Radix et Rhizomes. The extraction process was optimized using single factor exploration and Box-Behnken design-response surface analysis. The extraction rate was significantly improved when the molar ratio of choline chloride to 1,3-propanediol was 1:3.
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