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Dermal CIC-Rearranged Sarcoma With Neuroendocrine Differentiation Mimicking Merkel Cell Carcinoma.
J Cutan Pathol
December 2024
SkinPath Solutions, Smyrna, Georgia, USA.
Capicua transcriptional repressor (CIC)-rearranged sarcoma (CRS) is a rare and recently described tumor that most commonly affects patients between 15 and 30 years of age. It is an undifferentiated round cell malignancy, with a disease defining CIC fusion, with double homeobox 4 (DUX4) being the most common partner. Here, we report a 77-year-old woman who presented with a cutaneous thigh mass with a clinical morphology suggesting Merkel cell carcinoma.
View Article and Find Full Text PDFCharacteristics of Spontaneous Regression in Merkel Cell Carcinoma: A Retrospective Analysis of Patient and Tumor Features.
Clin Exp Dermatol
December 2024
Dermatology Department, Hospital Universitari de Bellvitge, Barcelona, Spain.
Article Synopsis
- Merkel cell carcinoma (MCC) is a serious skin cancer with a 4.5% incidence of complete spontaneous regression (CRS), which suggests a better prognosis for those patients.
- In a study of 112 MCC patients, the average age at diagnosis was 69, with tumors mainly found on the head and neck, and low immunosuppression rates among patients.
- The presence of Merkel cell polyomavirus (MCPyV) was linked to regression, indicating that immune responses and tumor characteristics, along with further research, are needed to understand this phenomenon better.
A Rare Case With a Review of Cutaneous Composite Hemangioendothelioma and the Role of Neuroendocrine Markers.
Am J Dermatopathol
December 2024
Department of Pathology and Lab Medicine, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, India; and.
Composite hemangioendothelioma comprises permutations of different histological patterns few of which have been found to have specific genetic alteration and immunohistochemical expression. It comprises retiform or epithelioid hemangioendothelioma-like areas, with a variable proportion of hemangioma or low-grade angiosarcoma-like areas. It was found to express neuroendocrine markers and was seen to have a worse prognosis in recurrence or distant metastasis.
View Article and Find Full Text PDFDiagnostic trajectories of patients with rare cancer in the Netherlands: results from a nationwide cross-sectional survey.
Support Care Cancer
November 2024
Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Article Synopsis
- Diagnosing rare cancers is tough and often takes a long time, according to a study that examined the experiences of 1541 patients in The Netherlands from GP visits to final diagnoses.
- Most patients (76.0%) started with a GP consultation, and while 76.3% were referred to a hospital within three months, 32.1% received incorrect diagnoses that led to unnecessary treatments.
- The study found significant differences in diagnosis timelines between solid and non-solid tumors, with patients experiencing varying waits; improving research on symptoms and clinical networks could help reduce these delays.
A Review of Non-Invasive Skin Imaging in Merkel Cell Carcinoma: Diagnostic Utility and Clinical Implications.
Cancers (Basel)
October 2024
First Dermatology Department, School of Medicine, Faculty of Health Sciences, Aristotle University, GR-54124 Thessaloniki, Greece.
Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous neuroendocrine malignancy characterized by its propensity for rapid growth and early regional and distant metastasis. Given its potentially lethal nature, accurate and timely diagnosis of MCC is of utmost importance. This review aims to describe non-invasive imaging methods that can serve as additional tools in the examination of MCC.
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