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The Molecular Mechanism Investigation of HBP-A Slows Down Meniscus Hypertrophy and Mineralisation by the Damage Mechanical Model.
J Cell Mol Med
December 2024
Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
HBP-A is the main active component of a traditional Chinese medicine Huaizhen Yanggan Capsule, for the remarkable treatment of knee osteoarthritis (KOA). This study aimed to elucidate the ameliorative effect of HBP-A on meniscus hypertrophy and mineralisation in KOA and the molecular mechanism of its action. An Hartley guinea pig model of KOA that underwent anterior cruciate ligament transection (ACLT) and a model of rat primary meniscus fibrochondrocytes (PMFs) were used to investigate the ameliorative effect of HBP-A on meniscal hypertrophy and calcification and its signal transduction mechanism of action.
View Article and Find Full Text PDFFinite element analysis on the human and guinea pig cochlear vibration patterns under bone conduction stimulations.
Sci Rep
October 2024
Department of Biomedical and Clinical Sciences, Linköping University, Stair D Level 11, 58185, Linköping, Sweden.
To compare the vibrational patterns of human and guinea pig cochleae accurately, we developed and validated a novel finite element model of the guinea pig, leveraging it to analyze vibrational patterns in the cochlea. This approach is mirrored in our examination of the human cochlear model, providing granular insights into the nuances of human bone conduction hearing. The comparative analysis reveals that the guinea pig cochlea mirrors human cochlear vibrational patterns, thus serving as an efficient proxy for exploring human cochlear function.
View Article and Find Full Text PDFMetabolic rate and saliva cortisol concentrations in socially housed adolescent guinea pigs.
J Comp Physiol B
December 2024
Department of Behavioral and Cognitive Biology, Faculty of Life Sciences, University of Vienna, University of Vienna Biology Building, Djerassiplatz 1, 1030, Vienna, Austria.
An individual's energetic demands and hence metabolic rate can strongly change during adolescence, a phase characterized by profound morphological, physiological, and endocrine changes. Glucocorticoid hormones (e.g.
View Article and Find Full Text PDFReversible opening of the blood-labyrinth barrier by low-pressure pulsed ultrasound and microbubbles for the treatment of inner ear diseases.
J Control Release
August 2024
Guangdong Provincial Key Laboratory of Advanced Drug Delivery & Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address:
Systemic drug administration provides convenience and non-invasive benefits for preventing and treating inner ear diseases. However, the blood-labyrinth barrier (BLB) restricts the transport of drugs to inner ear tissues. Ultrasound can stimulate specific areas and penetrate tissues, with the potential to overcome physiological barriers.
View Article and Find Full Text PDFAnalysis and validation of potential ICD-related biomarkers in development of myopia using machine learning.
Int Ophthalmol
February 2024
Department of Ophthalmology, The Third Affiliated Hospital of Southern Medical University, Number 183, Zhongshan Avenue West, Tianhe District, Guangzhou, 510630, People's Republic of China.
Purpose: We aimed to identify and verify potential biomarkers in the development of myopia associated with immunogenic cell death (ICD).
Methods: We download high myopia (HM) dataset GSE136701 from Gene Expression Omnibus. Differentially expressed genes in HM were identified to overlapped with ICD-related genes.
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