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Association of individual-based morphological brain network alterations with cognitive impairment in type 2 diabetes mellitus.
Front Neurol
January 2025
Department of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Objective: To investigate the altered characteristics of cortical morphology and individual-based morphological brain networks in type 2 diabetes mellitus (T2DM), as well as the neural network mechanisms underlying cognitive impairment in T2DM.
Methods: A total of 150 T2DM patients and 130 healthy controls (HCs) were recruited in this study. The study used voxel- and surface-based morphometric analyses to investigate morphological alterations (including gray matter volume, cortical thickness, cortical surface area, and localized gyrus index) in the brains of T2DM patients.
Anatomical, functional, and blood-born predictors of severity of brachycephalic obstructive airway syndrome severity in French Bulldogs.
Front Vet Sci
January 2025
Clinic of Reproductive Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Brachycephalic breeds suffer from respiratory distress known as brachycephalic obstructive airway syndrome (BOAS) and the multiple comorbidities associated with it. Targeted breeding toward a more BOAS-free phenotype requires accurate and least invasive detection of BOAS severity grades that are accessible and accepted by the breeders and kennel clubs. This study aimed to compare the-outcome of morphometric anatomical examination with functional tests such as exercise tests and plethysmography for the detection of BOAS severity in a group of 84 French Bulldogs.
View Article and Find Full Text PDFCT scan-based morphometric comparison of human and canine lumbar spine generates instrumental data for intervertebral disc percutaneous surgery.
Osteoarthr Cartil Open
March 2025
Nantes Université, Oniris, CHU Nantes, INSERM, Regenerative Medicine and Skeleton, RMeS, UMR 1229, Nantes, F-44000, France.
Objective: This study aimed to describe the anatomical landmarks for intervertebral disc (IVD) percutaneous approaches (transpedicular TPA and transannular TAA) using CT scans in humans and dogs for regenerative medicine research.
Method: CT scans of 57 human (30 supine, 27 prone) and 49 canine (29 chondrodystrophic, 20 non-chondrodystrophic) lumbar spines were analyzed. Morphometric data, cutaneous landmarks, and approach angles were measured, with additional sections assessing nerve root distances from TPA routes.
Functional differentiation of human dental pulp stem cells into neuron-like cells exhibiting electrophysiological activity.
Stem Cell Res Ther
January 2025
Department of Cell Biology and Histology, University of the Basque Country UPV/EHU, Leioa, Bizkaia, 48940, Spain.
Background And Aim: Human dental pulp stem cells (hDPSCs) constitute a promising alternative for central nervous system (CNS) cell therapy. Unlike other human stem cells, hDPSCs can be differentiated, without genetic modification, to neural cells that secrete neuroprotective factors. However, a better understanding of their real capacity to give rise to functional neurons and integrate into synaptic networks is still needed.
View Article and Find Full Text PDFTopographic and morphometric characterization of the humerii nutrient foramina and their implications for fracture repair and healing.
Sci Rep
January 2025
School of Life Sciences and Allied Health Professions, Anatomy Division, Kamuzu University of Health Sciences, Blantyre, Malawi.
Fractures of the humerus are common on the midshaft of the bone, often causing injury to the nutrient artery. Successful fracture repair and healing requires preservation of the blood supply to the long bones which is conveyed through the nutrient foramina (NF). The topography of long bone NF varies in different populations.
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