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TRPV4 as a Novel Regulator of Ferroptosis in Colon Adenocarcinoma: Implications for Prognosis and Therapeutic Targeting.
Dig Dis Sci
January 2025
Ningxia Medical University, Xing Qing Block, Shengli Street No.1160, Yin Chuan City, 750004, Ningxia Province, People's Republic of China.
Background: Colon adenocarcinoma (COAD) is a leading cause of cancer-related mortality worldwide. Transient receptor potential vanilloid 4 (TRPV4), a calcium-permeable non-selective cation channel, has been implicated in various cancers, including COAD. This study investigates the role of TRPV4 in colon adenocarcinoma and elucidates its potential mechanism via the ferroptosis pathway.
View Article and Find Full Text PDFIn vitro antitumor effects of methanolic extracts of three Ganoderema mushrooms.
Sci Rep
January 2025
Botany and Microbiology Department, Faculty of Science, Damietta University, New Damietta, 34517, Egypt.
Ganoderma mushrooms have a variety of pharmacological activities and may have antitumor effects. Therefore, the antitumor activity of the methanolic fruiting body extracts of three Ganoderma spp. will be evaluated by estimating cell viability, cell cycle parameters and the mode of cellular death.
View Article and Find Full Text PDFConsolidation With Second High Dose Therapy and Autologous Stem Cell Transplantation Is Associated With Improved Overall Survival in Patients With Multiple Myeloma in First Relapse.
Clin Lymphoma Myeloma Leuk
December 2024
Department of Hematology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Background: High dose chemotherapy and autologous stem cell transplantation (HDT/ASCT) remains the preferred first line consolidation strategy for newly diagnosed multiple myeloma (MM). However, The role of HDT/ASCT in first relapse is uncertain in the context of novel therapies. This study evaluates real-world outcomes of MM patients in first relapse, focusing on the role of consolidative HDT/ASCT.
View Article and Find Full Text PDFExtension of the Right Renal Vein in Deceased Donor Kidney Transplantation: A Literature Review and Analysis at Our Center.
Transplant Proc
January 2025
Servicio de Urología, Hospital Universitario Cruces, Barakaldo, Bizkaia, Spain.
Introduction: The length of the right renal vein is a crucial vascular factor in kidney transplantation. Its shorter length compared to the left renal vein complicates venous anastomosis. The aim of this article is to review the literature on this topic and provide data from our experience.
View Article and Find Full Text PDFSequestration of Cr(VI) onto polyethyleneimine-derivatized cellulose and its effect on the enzymatic degradation and microbiome viability.
Int J Biol Macromol
January 2025
Department of Chemistry, Birla Institute of Technology and Science (BITS), Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Medchal District, Hyderabad, Telangana 500078, India. Electronic address:
The extremely hazardous nature of Cr(VI) necessitates its sequestration in a sustainable and effective manner. Cellulose-derived materials, known for their eco-friendly properties, are widely employed in environmental remediation. To improve its adsorption capabilities for heavy metals, cellulose is often derivatized with moieties like amine, thiol, carboxylic acid, etc.
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