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Design of a Freely Accessible Web Application (Instrument for the Measurement of Balance in Primary Education, IMEP) for the Assessment of Static and Dynamic Balance in Children Aged 6-9 Years Based on Force Platforms.
J Funct Morphol Kinesiol
December 2024
Department of Sports Management and Physical Activity, Catholic University of Valencia, 46900 Valencia, Spain.
The proper development of balance is essential in the acquisition of a correct physical condition, as well as in the evolutionary follow-up at early ages, and its periodic evaluation is very relevant in the educational environment. : The objective of this research was to design an accessible web application for static and dynamic balance assessment, based on a force platform and motion analysis software. : The Single leg balance test (SLB), Tandem balance test (TBT), and Y balance test (YBT) were performed on a sample of 75 children aged 6 to 9 years.
View Article and Find Full Text PDFThe influence of hypoxia-mediated CEACAM6 upregulation on epithelial cell and macrophage response in the context of gastric cancer.
Eur J Clin Invest
December 2024
School of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, An OCC of Homi Bhabha National Institute, Khurda, Odisha, India.
Background: The hypoxic microenvironment is a key component of the gastric tumour niche. Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is upregulated in gastric cancer and is considered a novel biomarker for the disease. However, no prior studies have elaborated on the status of CEACAM6 and its role in the hypoxic gastric cancer niche.
View Article and Find Full Text PDFTailored polysaccharide entrapping metal-organic framework for RNAi therapeutics and diagnostics in atherosclerosis.
Bioact Mater
January 2025
Department of Biomaterials and Biomedical Technology, The Personalized Medicine Research Institute (PRECISION), University Medical Center Groningen (UMCG), University of Groningen, Ant. Deusinglaan 1, 9713 AV, Groningen, the Netherlands.
Article Synopsis
- Metal-organic frameworks (MOFs) are being explored as carriers for treating atherosclerosis, but creating more complex and effective versions usually requires complicated synthesis.
- This study introduces a straightforward method to create a multifunctional platform using a specially designed polymer that can trap different MOFs while boosting their stability and targeting capabilities for macrophages involved in atherosclerosis.
- Testing showed that this platform significantly improved MRI signal intensity and effectively reduced plaque area by 43% through the targeted delivery of therapeutic agents, demonstrating its potential for treating atherosclerosis and possibly other similar conditions.
Kappa-opioid receptor blockade in the inferior colliculus of prey threatened by pit vipers decreases anxiety and panic-like behaviour.
Acta Neuropsychiatr
October 2024
Laboratory of Neuroanatomy & Neuropsychobiology, Department of Pharmacology, School of Medicine of Ribeirão Preto of the University of São Paulo (FMRP-USP), Ribeirão Preto, São Paulo, Brazil.
The dorsal midbrain comprises dorsal columns of the periaqueductal grey matter and corpora quadrigemina. These structures are rich in beta-endorphinergic and leu-enkephalinergic neurons and receive GABAergic inputs from substantia nigra pars reticulata. Although the inferior colliculus (IC) is mainly involved in the acoustic pathways, the electrical and chemical stimulation of central and pericentral nuclei of the IC elicits a vigorous defensive behaviour.
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