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Point-of-care procalcitonin testing for lower respiratory tract infection in pulmonary outpatient care has limited value.
Pneumologie
August 2023
Respiratory medicine and Infectious disease, Hannover Medical School, Hannover, Germany.
Lower respiratory tract infections (LRTI) are frequently the reasons for patients to visit their general practitioners or lung specialists; however, physicians tend to prescribe antibiotics less frequently than necessary. A readily available biomarker could help distinguish between viral and bacterial cause of LRTI. The primary objective of our study was to determine the diagnostic accuracy of point-of-care testing (POCT) of procalcitonin (PCT) in identifying bacterial pneumonia in outpatients with LRTI.
View Article and Find Full Text PDFSystematic review and meta-analysis assessing the diagnostic test accuracy of procalcitonin in the diagnosis of invasive bacterial infections in febrile infants: a study protocol.
BMJ Open
August 2022
Wellcome-Wolfson Institute For Experimental Medicine, Queen's University Belfast, Belfast, UK.
Article Synopsis
- Young febrile infants are at increased risk of invasive bacterial infections, necessitating careful initial assessments that may involve blood biomarkers like C reactive protein (CRP) and procalcitonin (PCT), although PCT is not commonly used in the UK.
- The objective of the review is to evaluate the diagnostic accuracy of PCT in identifying invasive bacterial infections in infants under 91 days and compare its performance with CRP while determining the best PCT cut-off values.
- The study will systematically search various databases for relevant diagnostic accuracy studies, assess their quality, and present the findings in peer-reviewed journals and conferences, with completion aimed for 2023.
A retrospective controlled study of postoperative fever after posterior lumbar interbody fusion due to degenerative lumbar disease.
Medicine (Baltimore)
May 2022
Department of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Background: Postoperative fever is a common feature of spinal surgery. When fever occurs postoperatively in patients, surgeons are eager to rule out an infection. There are many reports about postoperative fever and infection; however, only a few have described the relationship between degenerative spinal disease and postoperative fever.
View Article and Find Full Text PDFPredictors of 1‑year mortality in ambulatory patients with advanced heart failure awaiting heart transplant.
Pol Arch Intern Med
February 2022
3rd Department of Cardiology, School of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland
Introduction: Heart failure (HF) is a complex syndrome involving diverse pathways and pathological processes that can manifest themselves in circulation as abnormal levels of various biomarkers.
Objective: The aim of the study was to assess the factors associated with a worse prognosis in patients with advanced HF awaiting heart transplant during a 1‑year follow‑up.
Patients And Methods: We prospectively assessed the data of 203 adult patients with advanced HF, who were hospitalized at our institution between 2016 and 2018.
Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: randomized controlled trial.
BMJ
June 2021
Department of Neurology, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Objective: To determine whether dietary interventions that increase n-3 fatty acids with and without reduction in n-6 linoleic acid can alter circulating lipid mediators implicated in headache pathogenesis, and decrease headache in adults with migraine.
Design: Three arm, parallel group, randomized, modified double blind, controlled trial.
Setting: Ambulatory, academic medical center in the United States over 16 weeks.
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