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[Experimental and clinical pulmonary pneumocystosis]. | LitMetric

AI Article Synopsis

  • The study compared rat lungs with hydrocortisone-induced pneumocystosis to necropsy materials from five AIDS patients using light and electron microscopy.
  • The researchers identified key similarities in the morphological features of pneumonia caused by Pneumocystis carinii in both rats and humans.
  • They outlined three distinct stages of lung pneumocystosis: latent, pronounced, and terminal (pneumocystic pneumonia), highlighting the roles of different fungal forms, surfactants, and various inflammatory cells.

Article Abstract

Rat lungs with hydrocortisone-induced pneumocystosis and a necropsy material from 5 patients with AIDS were studied light- and electron-microscopically. The identity of basic morphological features of lung pneumocystosis development in experiment and humans is demonstrated. Three main periods--latent, pronounced, terminal (pneumocystic pneumonia) are distinguished taking into account the relation of productive and vegetative forms of Pneumocystis carinii, state of the surfactants, type I alveolocytes and inflammation cells.

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