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Sodium zirconium cyclosilicate for MRAs optimization in HFrEF: lessons learned from the REALIZE-K trial.
Heart Fail Rev
January 2025
Centre d'Investigations Cliniques Plurithématique 1433 and INSERM U1116, CHRU Nancy, FCRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Institut Lorrain du Coeur Et Des Vaisseaux, CHRU de Nancy, Université de Lorraine, Nancy, France.
Mineralocorticoid receptor antagonists (MRAs) are a cornerstone of guideline-directed medical therapy for heart failure with reduced ejection fraction (HFrEF), offering significant benefits in reducing mortality and hospitalizations. However, their use is often constrained by the risk of hyperkalemia, particularly in patients with chronic kidney disease. Patiromer and sodium zirconium cyclosilicate (SZC), two novel potassium binders, have emerged as highly effective and safe tools for managing hyperkalemia and enabling the optimization of MRA therapy.
View Article and Find Full Text PDFArsenic, manganese, and iron concentration in groundwater of northwestern part of Bangladesh using self-organizing maps: Implication for health risk assessment.
Heliyon
January 2025
Department of Geology and Mining, University of Rajshahi, Rajshahi, 6205, Bangladesh.
Quantification of the non-linear relationship between arsenic (As) and physico-chemical parameters in groundwater through a Self-Organizing Map (SOM) was performed for the first time in Chapai-Nawabganj, Bangladesh. Due to the continuous assessment of groundwater quality, the spatial distribution of As with associated elements was observed for the aerial extent of contaminated groundwater. The results exhibited that 57 % and 31 % of groundwater samples (n = 35) exceeded the allowable limit of As according to the WHO recommended drinking water standard (10 μg/L) and Bangladesh Drinking Water Standard (BDWS) (50 μg/L), respectively.
View Article and Find Full Text PDFIs Routine Group and Save Sampling Necessary for Emergency Laparoscopic Appendicectomy?
Cureus
January 2025
General Surgery, Croydon University Hospital, London, GBR.
Background Laparoscopic appendicectomy is a commonly used approach for the surgical management of acute appendicitis. If complications arise, a blood transfusion may be necessary for patients undergoing emergency appendicectomy. The need for routine group and save (G&S) sampling prior to emergency laparoscopic appendicectomy remains a subject of ongoing discussion.
View Article and Find Full Text PDFRadioactive Iodine Therapy in Differentiated Thyroid Cancer: Summary of the Korean Thyroid Association Guidelines 2024 from Nuclear Medicine Perspective, Part-II.
Nucl Med Mol Imaging
February 2025
Department of Nuclear Medicine, Kyungpook National University Chilgok Hospital, Daegu, Korea.
Thyroid cancer, one of the most common endocrine tumors, generally has a favorable prognosis but remains a significant medical and societal concern due to its high incidence. Early diagnosis and treatment of differentiated thyroid cancer (DTC) significantly affect long-term outcomes, requiring the selection and application of appropriate initial treatments to improve prognosis and quality of life. Recent advances in technology and health information systems have enhanced our understanding of the molecular genetics of thyroid cancer, facilitating the identification of aggressive subgroups and enabling the accumulation of research on risk factors through big data.
View Article and Find Full Text PDFNuclear Medicine Imaging in Differentiated Thyroid Cancer: Summary of the Korean Thyroid Association Guidelines 2024 from Nuclear Medicine Perspective, Part-I.
Nucl Med Mol Imaging
February 2025
Department of Nuclear Medicine, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea.
Thyroid cancer, one of the most common endocrine tumors, generally has a favorable prognosis but remains a significant medical and societal concern due to its high incidence. Early diagnosis and treatment of differentiated thyroid cancer (DTC) significantly affect long-term outcomes, requiring the selection and application of appropriate initial treatments to improve prognosis and quality of life. Recent advances in technology and health information systems have enhanced our understanding of the molecular genetics of thyroid cancer, facilitating the identification of aggressive subgroups and enabling the accumulation of research on risk factors through big data.
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