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Novel mediators of aneurysm progression in bicuspid aortic valve disease.
J Mol Cell Cardiol
July 2019
Division of Cardiovascular Surgery, Toronto General Hospital Research Institute and Peter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada; Department of Surgery, Division of Cardiac Surgery, University of Toronto, Toronto, ON, Canada. Electronic address:
Bicuspid aortic valve (BAV) disease is a congenital abnormality that is associated with ascending aortic aneurysm yet many of the molecular mechanisms remain unknown. To identify novel molecular mechanisms of aneurysm formation we completed microarray analysis of the proximal (severely dilated) and distal (less dilated) regions of the ascending aorta from five patients with BAV. We identified 180 differentially expressed genes, 40 of which were validated by RT-qPCR.
View Article and Find Full Text PDFReimplantation for Marfan syndrome: If it ain't broke….
J Thorac Cardiovasc Surg
January 2018
Peter Munk Cardiac Centre, Division of Cardiac Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Progressive Aortic Dilation Is Regulated by miR-17-Associated miRNAs.
J Am Coll Cardiol
June 2016
Division of Cardiovascular Surgery, Toronto General Research Institute and Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada; Department of Surgery, Division of Cardiac Surgery, University of Toronto, Toronto, Ontario, Canada. Electronic address:
Background: Patients with a bicuspid aortic valve (BAV) are at increased risk for progressive aortic dilation associated with extracellular matrix (ECM) degradation by matrix metalloproteinases (MMP). However, the mechanisms responsible for initiating this process are unknown. In the heart, MMP activity is regulated by micro-ribonucleic acid-17 (miR-17)-related downregulation of tissue inhibitors of metalloproteinases (TIMP); a similar process may exist in the aorta.
View Article and Find Full Text PDFCorMatrix Extracellular Matrix Used for Valve Repair in the Adult: Is There De Novo Valvular Tissue Seen?
Ann Thorac Surg
June 2015
Department of Pathology, Toronto General Hospital/University Health Network, Toronto, Ontario, Canada. Electronic address:
Decellularized extracellular matrix from porcine intestinal submucosa is available as an approved material for the repair of tissues including cardiac structures. Although pathologic findings of explanted CorMatrix (CorMatrix Cardiovascular, Inc, Roswell, GA) used for valvular repair have been reported in the pediatric population, there is a paucity of data in the adult population. Herein, we report the histologic changes in explanted CorMatrix from 2 adults at 10 and 18 months post-implant.
View Article and Find Full Text PDFNative and prosthetic valve infective endocarditis: clinicopathologic correlation and review of the literature.
Malays J Pathol
August 2014
University Health Network and University of Toronto, Division of Cardiology, Toronto, Ontario, Canada.
Background: The incidence of infective endocarditis is 1.5-4.95 cases per 100,000 individuals per year, with a mortality of 14-46% 1-year post infection.
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