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18F-Fluorodeoxyglucose Uptake in PDGFRA-Mutant Gastrointestinal Stromal Tumors.
JAMA Netw Open
January 2025
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Importance: The D842V platelet-derived growth factor receptor α (PDGFRA) mutation identifies a molecular subgroup of gastrointestinal stromal tumors (GISTs), primarily resistant to standard tyrosine kinase inhibitors and with an overall more indolent behavior. Although functional imaging with 18F-fluorodeoxyglucose-labeled positron emission tomography ([18F]FDG-PET) plays a proven role in GISTs, especially in early assessment of tumor response, less is known about [18F]FDG uptake according to the GIST molecular subtypes.
Objective: To evaluate the degree of [18F]FDG uptake in PDGFRA-mutant GISTs and better define the role of functional imaging in this rare and peculiar subset of GISTs.
[This corrects the article DOI: 10.3389/fchem.2023.
View Article and Find Full Text PDFA comparison of routine [Ga]Ga-PSMA-11 preparation using Locametz and Illuccix kits.
EJNMMI Radiopharm Chem
December 2024
Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI, 48109, USA.
Background: Approval of Locametz and Illuccix kits for the manufacture of [Ga]Ga-PSMA-11 (gallium Ga68 gozetotide), a PET imaging agent for prostate cancer, as well as the corresponding therapeutic ([Lu]Lu-PSMA-617 Pluvicto), has led to a rapid increase in demand for [Ga]Ga-PSMA-11 PET imaging. Radiopharmaceutical manufacturers, using Ge/Ga generators, may decide to adopt Locametz and/or Illuccix kits, which requires a comparison to select the most suitable kit for day-to-day use. The objective of this article is to compare both kits and provide guidance for selecting one for routine use, as well as evaluate labeling consistency of both kits during routine production.
View Article and Find Full Text PDFTowards a General Method for Using Cyclotron-Produced Ga68 to Manufacture Clinical and Research Ga68 Tracers.
Molecules
November 2024
Division of Nuclear Medicine, Department of Radiology, University of Michigan, 1301 Catherine St. 2276 Medical Science I, Ann Arbor, MI 48109, USA.
The success of multiple nuclear medicine radiotherapeutics in treating cancer requires an increased supply of companion diagnostic imaging agents radiolabeled with gallium-68. Cyclotron production addresses the need for access to gallium-68 and has been validated for use with commercially produced sterile kits. For novel research tracers undergoing translational studies (IND or RDRC), developing and purchasing sterile kits is time- and cost-prohibitive.
View Article and Find Full Text PDFPredicting higher-risk growth patterns in invasive lung adenocarcinoma with multiphase multidetector computed tomography and 18 F-fluorodeoxyglucose PET radiomics.
Nucl Med Commun
February 2025
Department of Radiology.
Article Synopsis
- The study aims to create a predictive model to identify higher-risk growth patterns of invasive lung adenocarcinoma using multiphase MDCT and FDG PET imaging.
- A total of 203 patients were analyzed, with data divided into training and testing sets; various models were assessed based on their effectiveness in predicting higher-risk patterns from preoperative imaging.
- The combined Rad-Clin model showed the highest accuracy (AUC = 0.923), outperforming both individual radiomic and clinical models, suggesting its potential as a valuable tool in clinical decision-making for lung adenocarcinoma.
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