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| http://dx.doi.org/10.1136/bmj.317.7173.1609 | DOI Listing |
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Disposal practices, risk perceptions, and quantification of potential active pharmaceutical ingredients (APIs) from used human medicine in Upper Citarum River Basin.
Int J Environ Health Res
January 2025
Research Center for Limnology and Water Resources, National Research and Innovation Agency, Bogor, Indonesia.
This paper highlights potential active pharmaceutical ingredients (APIs) generations from improper disposal of medicines and captures the perceptions of key stakeholders - households and pharmaceutical actors in Upper Citarum River Basin (UCRB). Most pharmaceutical waste is disposed of with household waste, suggesting landfills are the most significant APIs contamination sources. We highlight the complex relationship between knowledge, risk perception, and behavioural intentions, stressing the relevance of risk perception as a mediator when studying how knowledge affects behaviour.
View Article and Find Full Text PDFPulmonary aspiration after activated charcoal in unintentional acute poisonings in childhood.
Arch Dis Child
January 2025
Pediatric Emergency Department, Cruces University Hospital Paediatric Emergencies, Barakaldo, Spain
Introduction: Although the administration of activated charcoal (AC) is considered safe, the associated risk of pulmonary aspiration explains certain reluctance of physicians to use this procedure. The objective of this study was to analyse the rate of pulmonary aspiration in children receiving AC after accidental ingestion of a toxic substance.
Methods: We carried out a substudy of a multicentre prospective registry-based cohort study including children presenting with acute poisoning to 58 paediatric emergency department (EDs) members of the Spanish Society of Pediatric Emergency Medicine between 2008 and 2022 on certain previously designated days.
A POCIS-based approach for the monitoring of pharmaceuticals in wastewater treatment plants: Calibration and deployment challenges.
Environ Pollut
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Department of Analytical and Applied Chemistry, School of Engineering, IQS-Universitat Ramon Llull, Via Augusta 390, 08017 Barcelona, Spain.
The impact of pharmaceuticals in aquatic environments requires complementary monitoring techniques to the more conventional grab sampling approach for an improved sample representativity. This study explores the application of Polar Organic Chemical Integrative Samplers (POCIS) in the analysis of a wide range of pharmaceutical residues in wastewater effluent, highlighting its advantages over grab sampling. Passive sampling techniques, extending sampling duration several days or weeks, provide continuous and representative data, improving the punctual nature of grab sampling.
View Article and Find Full Text PDFmTOR/HIF-1α pathway-mediated glucose reprogramming and macrophage polarization by Sini decoction plus ginseng soup in ALF.
Phytomedicine
January 2025
Department of Infectious Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu 610072, Sichuan Province, PR China. Electronic address:
Background: Acute liver failure (ALF) has a high mortality rate, and despite treatment advancements, long-term outcomes remain poor.
Purpose: This study explores the therapeutic targets and pathways of Sini Decoction plus Ginseng Soup (SNRS) in ALF using bioinformatics and network pharmacology, focusing on its impact on macrophage polarization through glucose metabolism reprogramming. The efficacy of SNRS was validated in an LPS/D-GalN-induced ALF model, and its optimal concentration was determined for in vitro macrophage intervention.
Investigating the Impact of Circulating MicroRNAs on Knee and Hip Osteoarthritis: Causal Links, Biological Mechanisms, and Drug Interactions.
Int J Mol Sci
December 2024
Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100010, China.
Osteoarthritis (OA), particularly in the knee and hip, poses a significant global health challenge due to limited therapeutic options. To elucidate the molecular mechanisms of OA and identify potential biomarkers and therapeutic targets, we utilized genome-wide association studies (GWAS) and cis-miRNA expression quantitative trait loci (cis-miR-eQTL) datasets to identify miRNAs associated with OA, revealing 16 that were linked to knee OA and 21 to hip OA. Among these, hsa-miR-1303 was significantly upregulated in both knee and hip OA (IVW: = 6.
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