The effect of acute ethanol intoxication (25% solution, intragastrically, 4 g/kg, 1 h) on the concentration of phospholipid fractions in different rat brain regions was studied. It was found that acute alcohol intoxication decreased the level of phosphatidylcholine and increased the concentration of phosphatidylethanolamine in the cerebellum of experimental animals. The cortex of large hemispheres showed a decreased amount of phosphatidylcholine and increased one of sphingomyelin. Possible mechanisms of these changes are discussed.
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