AI Article Synopsis
- This study examines how indomethacin, a cyclo-oxygenase inhibitor, affects body temperature regulation in burned rats, particularly its impact on fever modulation.
- Male Sprague-Dawley rats were instrumented to continuously record body temperature and activity levels after receiving full-thickness scald burns, with two groups receiving indomethacin and two receiving a control solution.
- The results showed that rats treated with indomethacin had significantly lower body temperatures compared to other groups, supporting the idea that the increased body temperature observed in burned rats may represent a true fever rather than hyperthermia.
Article Abstract
This study investigates the hypothesis that continuous administration of indomethacin (a cyclo-oxygenase inhibitor) will chronically reduce body temperature (TB) in burned rats (i.e., modulate "true" fever). Male Sprague-Dawley rats had radio transmitters and osmotic pumps (containing indomethacin) placed in the peritoneal cavity, and 7 days later large full-thickness scald burns were produced. Activity and TB were continually recorded through the 14th postburn day (PBD). There were 4 experimental groups: burn + indomethacin (B-In), n = 9; burn + polyethylene glycol (B-Peg), n = 6; control + indomethacin (C-In), n = 9; and control + polyethylene glycol (C-Peg), n = 6. From PBD 5 through PBD 10, the B-Peg group had consistently and significantly higher TB during light hours than the B-In, C-In, and C-Peg groups. From PBD 7 through PBD 12, the B-In group had an average TB during light hours significantly lower or not different than the C-In and C-Peg groups. These results support the hypothesis that in this burned-rat model chronically increased TB during the light hours may be "fever" (rather than hyperthermia) and that the final effector link could be a prostanoid because changes in activity do not explain the changes in body temperature.
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