Objective: Currently, there is no documentation of the efficacy of venlafaxine (a serotonin norepinephrine reuptake inhibitor) in the treatment of dysthymia. This open-label pilot investigation examined the efficacy and tolerability of venlafaxine in patients with primary dysthymia without concomitant major depression.
Methods: Fifteen patients were treated with venlafaxine for 12 weeks, with a dose range of 75 mg to 225 mg daily (taken orally), and symptom changes were measured using standard instruments including the Hamilton Depression Rating Scale (HAM-D).
Results: Significant changes from pretreatment to posttreatment were observed (p < 0.001). Using the standard criteria of a 50% reduction in HAM-D scores, 73.3% of patients were rated as responders. About two-thirds of the patients reported adverse events, which were mostly mild and brief in duration.
Conclusion: Venlafaxine may be useful in the treatment of primary dysthymia but placebo-controlled studies are required for confirmation.
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Article Synopsis
- Dysthymia, a chronic and less severe form of depression, leads to significant impairments but has received less research focus than major depressive disorder (MDD).
- The authors conducted a thorough review of treatment options for dysthymia by analyzing original studies retrieved from PubMed, specifically targeting samples diagnosed according to established DSM criteria.
- Several antidepressants, like sertraline and paroxetine, showed benefits compared to placebo, but findings on psychotherapy are inconclusive due to limited studies and various methodological issues such as small sample sizes and lack of blinding.
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