Chronic fatigue syndrome differs from fibromyalgia. No evidence for elevated substance P levels in cerebrospinal fluid of patients with chronic fatigue syndrome.

B Evengard C G Nilsson G Lindh L Lindquist P Eneroth S Fredrikson L Terenius K G Henriksson

Pain

Department of Infectious Diseases, Karolinska Institute at Huddinge Hospital, Stockholm, Sweden Unit for Applied Biochemistry, Clinical Research Center at NOVUM, Karolinska Institute at Huddinge Hospital, Stockholm, Sweden Department of Neurology, Karolinska Institute at Huddinge Hospital, Stockholm, Sweden Department of Drug Dependence Research, Karolinska Hospital, Stockholm, Sweden Neuromuscular Unit and Pain Clinic, University Hospital, Linköping, Sweden.

Published: November 1998

Levels of substance P were determined in the cerebrospinal fluid (CSF) in 15 patients with chronic fatigue syndrome (CFS). All values were within normal range. This is in contrast to fibromyalgia (FM). The majority of patients with FM have increased substance P values in the CSF. The results support the notion that FM and CFS are different disorders in spite of overlapping symptomatology.

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http://dx.doi.org/10.1016/S0304-3959(98)00134-1	DOI Listing

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