In summary, I believe that the qualities that Havel exemplifies in his leadership style, namely, his sense of the absurd, his altruism in reluctantly assuming the responsibility for something he started, his amateurish political style, his apologetic stance, and his apolitical ideologies all serve to make him a flexible and idealistic leader who can, indeed must, be trusted and admired by his followers. Despite these personal and leadership qualities, it was fateful that Vaclav Havel was born in a place where his exemplary qualities could be used. Perhaps if he were born in another nation that did not have such a strong tradition of philosopher-kings or a peace-loving nature, he would not have been able to attain such political and idealistic heights. Also, if he had been born just a few decades earlier, he may not have been the recipient of such benevolent treatment from the Soviet system. In another time and place we may have never had the luxury of basking in the ideas and using the courage and fortitude exemplified in his deeds, which inspired his country to greater plateaus. Vaclav Havel and what he symbolizes are inseparable from his history and his cultural experience. We, as the audience in his absurd play, are forever linked to the author and are grateful for the chance to watch the play unfold. It will be interesting to examine the way in which his leadership style changes as a consequence of his illness. Already, those close to him have noticed personality changes that indicate a shift toward a more direct and abrasive demeanor. Post (1980) has written extensively about the critical role played by aging and illness among leaders. Part of what makes this work exciting is that Vaclav Havel is a contemporary leader whose life continues to undergo strange and unexpected twists and turns.
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http://dx.doi.org/10.1521/jaap.1.1998.26.2.233 | DOI Listing |
Nat Commun
September 2024
Department of Chemistry, Columbia University, New York, NY, 10027, USA.
Nature
June 2024
Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Psychedelic substances such as lysergic acid diethylamide (LSD) and psilocybin show potential for the treatment of various neuropsychiatric disorders. These compounds are thought to mediate their hallucinogenic and therapeutic effects through the serotonin (5-hydroxytryptamine (5-HT)) receptor 5-HT (ref. ).
View Article and Find Full Text PDFNat Commun
June 2021
Department of Chemistry, Columbia University, New York, NY, USA.
Mitragynine (MG) is the most abundant alkaloid component of the psychoactive plant material "kratom", which according to numerous anecdotal reports shows efficacy in self-medication for pain syndromes, depression, anxiety, and substance use disorders. We have developed a synthetic method for selective functionalization of the unexplored C11 position of the MG scaffold (C6 position in indole numbering) via the use of an indole-ethylene glycol adduct and subsequent iridium-catalyzed borylation. Through this work we discover that C11 represents a key locant for fine-tuning opioid receptor signaling efficacy.
View Article and Find Full Text PDFACS Chem Neurosci
June 2020
Laboratorio de Sı́ntesis Orgánica, Departamento de Quı́mica Orgánica, Facultad de Quı́mica, Universidad de la República, Montevideo 11200, Uruguay.
Anecdotal reports and open-label case studies in humans indicated that the psychedelic alkaloid ibogaine exerts profound antiaddictive effects. Ample preclinical evidence demonstrated the efficacy of ibogaine, and its main metabolite, noribogaine, in substance-use-disorder rodent models. In contrast to addiction research, depression-relevant effects of ibogaine or noribogaine in rodents have not been previously examined.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
December 2019
Department of Chemistry and RECETOX, Faculty of Science, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.
Reversible covalent bonds play a significant role in achieving the high-yielding synthesis of mechanically interlocked molecules. Still, only a handful of such bonds have been successfully employed in synthetic procedures. Herein, we introduce a novel approach for the fast and simple preparation of interlocked molecules, combining the dynamic bond character of bis(acyloxy)iodate(I) anions with macrocyclic bambusuril anion receptors.
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