The author provides a review of the relationship between Harvey Cushing and William Osler. Dr. Osler's influence on Cushing's role as a leader in neurosurgery is examined. Some basic principles of a neurosurgical "Way of Life" are reviewed.
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| http://dx.doi.org/10.3171/jns.1998.89.6.0901 | DOI Listing |
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Headache in radiologically isolated syndrome: a hint toward imminent conversion: a case report.
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View Article and Find Full Text PDFGlobal disparities in neurosurgical care necessitate innovations addressing affordability and accuracy, particularly for critical procedures like ventriculostomy. This intervention, vital for managing life-threatening intracranial pressure increases, is associated with catheter misplacement rates exceeding 30% when using a freehand technique. Such misplacements hold severe consequences including haemorrhage, infection, prolonged hospital stays, and even morbidity and mortality.
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High cellular plasticity state of medulloblastoma local recurrence and distant dissemination.
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Medulloblastoma (MB), a heterogeneous pediatric brain tumor, poses challenges in the treatment of tumor recurrence and dissemination. To characterize cellular diversity and genetic features, we comprehensively analyzed single-cell/nucleus RNA sequencing (sc/snRNA-seq), single-nucleus assay for transposase-accessible chromatin sequencing (snATAC-seq), and spatial transcriptomics profiles and identified distinct cellular populations in SHH (sonic hedgehog) and Group_3 subgroups, with varying proportions in local recurrence or dissemination. Local recurrence showed higher cycling tumor cell enrichment, whereas disseminated lesions had a relatively notable presence of differentiated subsets.
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