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Atorvastatin-Induced Liver Injury With Concurrent Rhabdomyolysis After a Positive Rechallenge.
ACG Case Rep J
January 2025
Medstar Transplant Institute, MedStar Georgetown University Hospital, Washington, DC.
Statin-induced liver injury has been widely described. However, cases of clinically significant liver injury are rare. We present a 56-year-old woman who developed atorvastatin-induced grade III acute liver injury with concurrent rhabdomyolysis that worsened after rechallenging, which highlighted the need for pharmacovigilance with statins.
View Article and Find Full Text PDFResazurin dye is an in vivo sensor of kidney tubular function.
Kidney Int
December 2024
Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA. Electronic address:
Glomerular filtration rate (GFR) is the main functional index of kidney health and disease. Currently, no methods are available to directly measure tubular mass and function. Here, we report a serendipitous finding that the in vitro cell viability dye resazurin can be used in mice as an exogenous sensor of tubular function.
View Article and Find Full Text PDFNon-oliguric acute renal failure secondary to a potentially lethal dose of caffeine with acute intoxication: a case report.
BMC Nephrol
December 2024
Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura, 247-8533, Kanagawa, Japan.
Background: Recently, the incidence of caffeine intoxication has been on an upward trend, with severe outcomes. However, acute kidney injury (AKI) resulting from renal pathologies secondary to caffeine intoxication is rare, and the pathophysiological mechanisms underlying AKI are unclear.
Case Presentation: A female patient in her 20s ingested an over-the-counter drug containing caffeine.
A liver transplant patient developed renal injury on tacrolimus and experienced worsening renal function and rhabdomyolysis after switching to sirolimus: a case report.
BMC Nephrol
December 2024
Department of Nephrology, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, 610041, China.
Article Synopsis
- A 54-year-old male liver transplant patient initially treated with tacrolimus developed renal dysfunction, prompting a switch to sirolimus for immunosuppression.
- After starting sirolimus, the patient experienced worsening renal function and later developed rhabdomyolysis, linked to high sirolimus levels in serum and specific kidney damage seen in histopathology.
- Reducing the sirolimus dosage led to normalization of muscle enzyme levels and improved kidney function, emphasizing the need for careful monitoring of sirolimus concentrations to prevent such serious side effects.
Rhabdomyolysis and Pigment Nephropathy - An Uncommon Manifestation of Eucalyptus Oil Consumption.
Indian J Nephrol
June 2024
Department of Pathology, KMCH IHSR, Coimbatore, Tamil Nadu, India.
Eucalyptus oil consumption is well known to cause adverse effects on central nervous system like seizures, ataxia and unconsciousness. No antidote is available and treatment is largely supportive. We report a case of rhabdomyolysis with pigment cast nephropathy and acute kidney injury in a young female following eucalyptus oil consumption and its successful management.
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