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Effects of Hydrogen Sulfide at Normal Body Temperature and in the Cold on Isolated Tail and Carotid Arteries from Rats and TRPA1 Knockout and Wild-Type Mice.
Biomedicines
December 2024
Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pecs, 7624 Pecs, Hungary.
Hydrogen sulfide (HS) is a gasotransmitter that modulates vascular tone, causing either vasodilation or vasoconstriction depending on the vascular bed, species, and experimental conditions. The cold-sensitive transient receptor potential ankyrin-1 (TRPA1) channel mediates HS-induced effects; however, its contribution to the vasomotor responses of different arteries at different temperatures has remained unclear. Here, we aimed to fill this gap by comparing the effects of sodium sulfide (NaS), which is a fast-releasing HS donor, on the isolated carotid and tail skin arteries of rats and mice at cold and normal body temperature with wire myography.
View Article and Find Full Text PDFThe novel estrogen receptor beta agonist EGX358 and genotype influence memory, vasomotor, and anxiety outcomes in an Alzheimer's mouse model.
Front Aging Neurosci
November 2024
Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI, United States.
Introduction: Alzheimer's disease (AD) prevalence and severity are associated with increased age, female sex, and apolipoprotein E4 (APOE4) genotype. Although estrogen therapy (ET) effectively reduces symptoms of menopause including hot flashes and anxiety, and can reduce dementia risk, it is associated with increased risks of breast and uterine cancer due to estrogen receptor alpha (ERα)-mediated increases in cancer cell proliferation. Because ERβ activation reduces this cell proliferation, selective targeting of ERβ may provide a safer method of improving memory and reducing hot flashes in menopausal women, including those with AD.
View Article and Find Full Text PDFMenopause and Quality of Life Among Greek Women in Rural Areas.
Cureus
October 2024
Midwifery, Faculty of Health and Care Sciences, University of West Attica, Athens, GRC.
Introduction The World Health Organization defines menopause as the permanent termination of ovarian function and the absence of menstruation for a minimum of 12 months. A woman's quality of life and health may be affected by menopause, a physiological condition that is typically accompanied by vasomotor, physical, and psychological disorders. Also, menopausal women experience a wide range of psychological symptoms, such as irritability, anxiety, sadness, and depression.
View Article and Find Full Text PDFExploring the Benefits of Herbal Medicine Composite 5 (HRMC5) for Skin Health Enhancement.
Curr Issues Mol Biol
October 2024
Plant Cell Research Institute of BIO-FD&C Co., Ltd., Incheon 21990, Republic of Korea.
The skin, as the body's largest organ, is vital for protecting against environmental stressors, regulating temperature, and preventing water loss. Here, we examined the potential of a mixture of five traditional Korean herbal extracts-, , , , and -referred to as herbal medicine composite 5 (HRMC5) for enhancing skin health and managing menopausal symptoms. High-performance liquid chromatography identified 14 bioactive compounds, including flavonoids, phenolic acids, anthraquinones, and alkaloids.
View Article and Find Full Text PDFCharacterization of microcirculatory endothelial functions in a D-Galactose-induced aging model.
Microvasc Res
January 2025
Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China; International Center of Microvascular Medicine, Chinese Academy of Medical Sciences, Beijing 100005, China. Electronic address:
Article Synopsis
- * Mice were injected with D-Galactose to induce aging, and various tests evaluated aging indicators, oxidative stress, inflammation, and changes in microvascular structure and blood flow.
- * Results showed that aging mice had increased oxidative stress, changes in microvascular structure, reduced blood flow, and overall signs of endothelial dysfunction, indicating that D-Galactose contributes to microcirculatory aging.
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