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A Brief History of Nuclear Medicine Imaging of Infection.
J Infect Dis
October 2023
Department of Radiology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
For nearly 50 years, nuclear medicine has played an important role in the diagnosis of infection. Gallium citrate Ga 67 was one of the first, if not the first, radionuclide used for this purpose. Unfavorable imaging characteristics, a lack of specificity, and the long interval (2-3 days) between administration and imaging spurred the search for alternatives.
View Article and Find Full Text PDFCase Report: IgG4-related kidney disease complicated by interstitial pneumonia.
F1000Res
September 2023
Department of Nephrology, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
Immunoglobulin G4 (IgG4)-related disease is a systemic inflammatory disorder characterized by tubulointerstitial nephritis with IgG4-positive plasma cell infiltration. We report the case of an 84-year-old male who presented with a history of dyspnea on exertion and cough. The lymph nodes were palpated in the axilla.
View Article and Find Full Text PDF[Ga]Ga-DATA-LM4, a PET Radiotracer in the Diagnosis of SSTR-Positive Tumors: Preclinical and First Clinical Results.
Int J Mol Sci
November 2022
Molecular Radiopharmacy, INRaSTES, NCSR "Demokritos", GR-15310 Athens, Greece.
Radiolabeled somatostatin subtype 2 receptor (SST2R)-antagonists have shown advantageous profiles for cancer theranostics compared with agonists. On the other hand, the newly introduced hybrid chelator (6-pentanoic acid)-6-(amino)methyl-1,4-diazepinetriacetate (DATA) rapidly binds Ga-68 (t: 67.7 min) at much lower temperature, thus allowing for quick access to "ready-for-injection" [Ga]Ga-tracers in hospitals.
View Article and Find Full Text PDFAscorbate Preferentially Stimulates Gallium-67 Uptake in Glioblastoma Cells.
J Nucl Med Radiat Ther
July 2022
Department of Radiation Oncology, University of Iowa; Iowa City, IA, USA.
Gallium is a tri-valent p-block metal that closely mimics tri-valent iron. Gallium is internalized into cells transferrin receptor-mediated endocytosis. Both Ga-67 and Ga-68 are radionuclides that can be radiolabeled to various bioactive compounds for clinical imaging procedures to visualize tumors and sites of inflammation.
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