AI Article Synopsis
- A new virus, not related to known calf diarrhea viruses, caused intestinal lesions in germ-free calves, with symptoms developing quickly—sometimes within just 8 hours of infection.
- The virus formed unique fringed particles about 100 nm in size, leading to severe illness lasting only 24 hours in bacteria-free calves, but higher mortality when combined with pathogenic bacteria like E. coli.
- Infection primarily damaged the small intestinal villi, resulting in syncytial cells filled with viruses before the animals showed signs of diarrhea.
Article Abstract
Intestinal lesions caused by a virus serologically unrelated to the calf diarrheal rotavirus or coronavirus were studied in gnotobiotic calves. The virion purified from feces from infected calves was a fringed particle with a diameter of about 100 nm. The incubation period from time of inoculation per orum to onset of diarrhea in calves was as short as 8 hours. The viral infection in bacteria-free calves or calves not contaminated with pathogenic bacteria caused severe illness for only 24 hours. When bacteria such as the K99 antigen Escherichia coli were present, the combined infection caused mortality. Lesions occurred only in the small intestinal villous epithelium. Calves euthanatized shortly before or after the onset of diarrhea had developed villous epithelial cell syncytia that contained numberous virions in the cytoplasm. Within 2 to 3 hours after onset of diarrhea, the infected cells were shed and the villi had denuded tips or had cuboidal to squamous epithelial cells.
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