Objective: To construct a complex indicator, the Health Index, for the determination of the general health profile of the population and to assess the time trends of the latter in the male population of Tallinn, the capital of Estonia.
Design: Three epidemiological studies of cardiovascular diseases (CVD) risk factor involving independent random samples of the male population of Tallinn aged 30-59 y were carried out in 1981/82 (survey I), in 1984/85 (survey II) and in 1992/94 (survey III), the total number of participants was 5019. The screening procedure included standard epidemiological methods. The cohorts of the surveys I and II were followed up for 11 y on average; 457 deaths of cases were registered during that period. For the assessment of the general health profile of the population the Health Index was constructed on the basis of mortality follow-up data of the above mentioned two cohorts by means of the survival analysis methods using SAS (Statistical Analysis System). 20 variables were tested, 11 of them were selected as statistically significant for the prediction of total mortality: systolic blood pressure, heart rate, coronary heart disease (CHD) status (P < 0.0001), total cholesterol (TC), TC2, body mass index (BMI), BMI2, education, smoking, alcohol consumption (P < 0.01), marital status (P < 0.05). The predictive ability of the Health Index for CHD, CVD and total mortality was confirmed by analysing the age-adjusted relative risks according to the deciles of the Health Index.
Results: The Health Index was used to determine the general health profile of the male population of Tallinn aged 30-59 y at surveys I, II and III and for the assessment of its time trends between the three surveys (1981/82-1992/94). We have established an improvement of the health profile in the studied population from survey I to survey II and a further improvement for those aged over 40 y from the surveys II and III.
Conclusion: The Health Index should be regarded as a valuable tool for the assessment of health trends in the population. The mortality decline expected in this study was confirmed by observed mortality trends in the Estonian male population.
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http://dx.doi.org/10.1038/sj.ph.1900484 | DOI Listing |
Nicotine Tob Res
January 2025
Faculty of Public Health & Policy, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, United Kingdom.
Introduction: Oral nicotine pouches (ONPs) are increasingly prevalent among young people and feature widely within social media content. This study systematically analyzes the most viewed videos on TikTok relating to ZYN (the most popular ONP, manufactured by a subsidiary of Philip Morris International) to understand their content sentiment and patterns, as well as the demographics and potential commercial biases of their creators.
Methods: We used an Apify scraper in July 2024 to collect URLs and metadata for the top 100 most viewed videos on TikTok under the #ZYN hashtag.
Hum Cell
January 2025
Department of Tumor Pathology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji, Fukui, 910-1193, Japan.
Only a few human ovarian endometrioid carcinoma cell lines are currently available, partly due to the difficulty of establishing cell lines from low-grade cancers. Here, using a cell immortalization strategy consisting of i) inactivation of the p16-pRb pathway by constitutive expression of mutant cyclin-dependent kinase 4 (R24C) (CDK4) and cyclin D1, and ii) acquisition of telomerase reverse transcriptase (TERT) activity, we established a human ovarian endometrioid carcinoma cell line from a 46-year-old Japanese woman. That line, designated JFE-21, has proliferated continuously for over 6 months with a doubling time of ~ 55 h.
View Article and Find Full Text PDFDiscov Oncol
January 2025
School of Medicine, Anhui University of Science & Technology, Huainan, China.
Background: Lung adenocarcinoma is one of the most common malignant tumors worldwide. Its complex molecular mechanisms and high tumor heterogeneity pose significant challenges for clinical treatment. The manganese ion metabolism family plays a crucial role in various biological processes, and the abnormal expression of the NUDT3 gene in multiple cancers has drawn considerable attention.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, UCSI University, No. 1, Jalan Menara Gading, Taman Connaught, Cheras, Kuala Lumpur, 56000, Malaysia.
The third most prevalent type of cancer in the world, colorectal cancer, poses a significant treatment challenge due to the nonspecific distribution, low efficacy, and high systemic toxicity associated with chemotherapy. To overcome these limitations, a targeted drug delivery system with a high cytotoxicity against cancer cells while maintaining a minimal systemic side effects represents a promising therapeutic approach. Therefore, the aim of this study was to develop an efficient gold nanocarrier for the targeted delivery of the anticancer agent everolimus to Caco-2 cells.
View Article and Find Full Text PDFInt J Audiol
January 2025
Cochlear Center for Hearing and Public Health, Johns Hopkins University, Baltimore, MD, USA.
Objectives: This longitudinal experimental study aimed to profile audiometric hearing loss, explore the feasibility and efficacy of low-cost hearing devices, and examine their social and emotional impact on participants in South Sudan, a low-resource humanitarian setting.
Design: We performed pure tone hearing screenings on adults with self-reported hearing disability, randomly providing eligible participants with one of two inexpensive devices-Asana Pro 800, a non-customizable hearing device fit unilaterally, or the Super Ear SE9000, a hand-held amplifier with headphones given one per individual.
Study Sample: Between October 2022 and January 2023, 142 adults underwent hearing screening at the Juba Teaching Hospital ENT clinic, of whom 19 eligible individuals were provided with hearing devices.
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