Different combinations of radical mastectomy, radiotherapy and cycle polychemotherapy were compared in 330 patients with T2N2 and T3-4N0-2M0 breast cancers: preoperative radiotherapy followed by surgery and adjuvant chemo-hormonal therapy (CT/HT)-118: neoadjuvant polychemotherapy (neCT) combined with preoperative radiation, surgery and adjuvant CT/HT-105; surgery, postoperative radiotherapy (PoRT) and adjuvant CT/HT-51, and neoCT followed by surgery, PoLT and adjuvant CT/HT-56. Advantage offered by postoperative radiotherapy proved significant only in the T2N2 and T3N1M0 groups and only in cases of combined PoLT and neoadjuvant polychemotherapy. Neoadjuvant polychemotherapy proved advantageous only in combination with postoperative surgery, and, on the whole, its application was as effective as adjuvant administration of cytostatic drugs. However, considering significant increase in recurrence-free survival in neoCT-sensitive patients within the first years of follow-up, one can expect to obtain higher stable effect in application of methods leading to more frequent complete regression.
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