The ionic hemolysis in healthy babies during the first year of life was studied. The hemolysis in low as well as high ionic strength was observed. It was found that the hemolysis in low ionic strength is lower during the first year of life in comparison with adults. However, hemolysis in high ionic strength was significantly lower only between 1-15 days old newborns. The ionic hemolysis in relation to the other biophysical factors in newborns is discussed.
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Gels
December 2024
Clinical Biochemistry Laboratory, Near East University Hospital, Nicosia 99138, North Cyprus, Turkey.
This study examines the hemocompatibility of gellan-gum-based hybrid hydrogels, with varying gellan-gum concentrations and constant sodium alginate and silk fibroin concentrations, respectively, in accordance with ISO 10993-4 standards. While previous studies have focused on cytocompatibility, the hemocompatibility of these hydrogels remains underexplored. Hydrogels were formulated with 0.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
College of Material Science and Engineering, Huaqiao University, Engineering Research Center of Environment-Friendly Functional Materials, Ministry of Education, Xiamen 361021, China. Electronic address:
To improve the solubility, antimicrobial efficacy, antioxidant capacity, and biocompatibility of chitosan for broader applications, a series of novel ionic chitosan derivatives were synthesized in this study by amidating chitosan with carboxyl pyridinium sulfonate. These derivatives were characterized through various analytical techniques, including FTIR, H NMR, UV, TGA, and XRD. Proton NMR was particularly utilized to determine the degree of substitution.
View Article and Find Full Text PDFJ Control Release
January 2025
School of Pharmacy and Technology Management, SVKM's Narsee Monjee Institute of Management Studies (NMIMS) Deemed-to-University, Jadcherla, Hyderabad 509301, India.
This study presents the development of melatonin-coated lactoferrin-chitosan nanoparticles (ETP-CS-LF-MLT-NPs) using ionic gelation and carbodiimide coupling for colorectal cancer treatment. The nanoparticles were characterized by an average size of 208.7 ± 1.
View Article and Find Full Text PDFJ Microencapsul
December 2024
Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India.
Aim: The study aimed to enhance phloretin's oral absorption and systemic availability through nanoencapsulation within biodegradable polymers, improving its anti-oxidant and cardioprotective potential.
Methods: Phloretin-loaded polymeric nanocomposites were prepared using ionic gelation and optimised for yield, encapsulation, loading, particle size, PdI and zeta potential. The formulation was characterised by FTIR, XRD, FESEM and MS.
Int J Biol Macromol
November 2024
Polymer Technology, School of Chemical Engineering, Aalto University, Kemistintie 1, 02150 Espoo, Finland. Electronic address:
This study investigates a novel all-polysaccharide hydrogel composed of tragacanth gum (TG) and cellulose nanocrystals (CNCs), eliminating the need for toxic crosslinkers. Designed for potential tissue engineering applications, these hydrogels were fabricated using 3D printing and freeze-drying techniques to create scaffolds with interconnected macropores, facilitating nutrient transport. SEM images revealed that the hydrogels contained macropores with a diameter of 100-115 μm.
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