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Impact of glucocorticoids on patients' quality of life: a qualitative study assessing face validity and feasibility of the Steroid PRO in patients with inflammatory gastroenterology, respiratory and dermatology conditions.
BMJ Open
February 2025
University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK
Objectives: The Steroid PRO is a treatment-specific patient-reported outcome questionnaire which measures the impact of glucocorticoids on health-related quality of life. It has 15 items grouped into 4 domains (Social impact, Impact on Appearance, Psychological Impact and Treatment Concerns). Initially developed and validated in rheumatic diseases, the Steroid PRO demonstrates potential for broader application in patients with other inflammatory conditions.
View Article and Find Full Text PDFTargeting p38 MAPK signaling pathway and neutrophil extracellular traps: An important anti-inflammatory mechanism of Huangqin Qingre Chubi Capsule in rheumatoid arthritis.
Int Immunopharmacol
February 2025
Department of Rheumatology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230031, China; Institute of Rheumatology, Anhui Academy of Chinese Medicine, Hefei, Anhui 230031, China.
Rheumatoid arthritis (RA) is a common chronic autoimmune disease. Neutrophils release and their extracellular traps (NETs) tend to result in synovial inflammation and cartilage damage. Huangqin Qingre Chubi Capsule (HQC) is an important herbal formulation for RA treatment and has been used for many years.
View Article and Find Full Text PDFTotal joint arthroplasty of the thumb CMC joint.
Arch Orthop Trauma Surg
January 2025
Department of Orthopaedics and Traumatology, Second Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic.
Purpose Of The Study: Rhizarthrosis-osteoarthritis of the thumb carpometacarpal (CMC) joint is usually a primary idiopathic disease. Total joint arthroplasty (TJA) is one of the surgical treatment options for symptomatic advanced thumb CMC arthritis. This retrospective study aims to evaluate the mid-term functional and radiological results of TJA with the minimum follow-up period of 3 years after the surgery.
View Article and Find Full Text PDFPrevalence of pulmonary hypertension and associated factors among rheumatic heart disease patients in Ethiopia.
BMC Cardiovasc Disord
January 2025
Department of Internal Medicine, Collage of Medicine and Health Science, Debre Markos University, Debre Markos, Ethiopia.
Background: In developing countries evidences regarding pulmonary hypertension (PH) in rheumatic heart disease (RHD) patients are lacking, despite being responsible for significant morbidity and mortality. As a result, identifying the factors that influence PH is crucial to improve the quality of care.
Objective: To determine prevalence of pulmonary hypertension and its associated factors among rheumatic heart disease patients at the public hospitals of Bahir Dar city, Ethiopia.
Article Synopsis
- The optimal treatment for B2 glenoid morphology in young, active osteoarthritis patients is debated, with various options like hemiarthroplasty, total shoulder arthroplasty (TSA), and reverse TSA available, each having pros and cons.
- Eccentric glenoid reaming can be effective but risks damaging the bone structure, potentially complicating future surgeries, while bone grafting, though beneficial for some, comes with high complication rates.
- Reverse TSA offers a more stable alternative when correcting version and inclination proves difficult, as it adapts better to glenoid deformities and maintains functionality with reduced bone stock.
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