Four experiments investigated the interactive effect of text-provided elaborations and prior knowledge on text comprehension and memory. Subjects read 28 episodes, half of which were associated with well-known people and the other half with unknown people. In Experiment 1, text-provided elaborations enhanced recall only when the reader did not have a high level of prior knowledge. The findings from Experiment 1 were hypothesized to be the result of readers generating relevant elaborations during text comprehension. Experiment 2 supported this hypothesis by providing evidence of self-generated elaborations. The results from Experiments 3 and 4 extended these findings by showing that readers with high prior knowledge automatically generate causally relevant elaborations when the sentences have a low relation.
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ATS Sch
January 2025
Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland.
Rapid accumulation of knowledge and skills by trainees in the intensive care unit assumes prior mastery of clinically relevant core physiology concepts. However, for many fellows, their foundational physiology knowledge was acquired years earlier during their preclinical medical curricula and variably reinforced during the remainder of their undergraduate and graduate medical training. We sought to assess the retention of clinically relevant pulmonary physiology knowledge among pulmonary and critical care medicine (PCCM) and critical care medicine (CCM) fellows.
View Article and Find Full Text PDFAIDS Patient Care STDS
January 2025
Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.
Bacterial sexually transmitted diseases (STDs) remain prominent in the United States among gay, bisexual, and other men who have sex with men (GBMSM). Doxycycline for post-exposure prophylaxis (DoxyPEP) is a regimen by which the antibiotic doxycycline is taken after sex to prevent bacterial STDs, such as, chlamydia, gonorrhea, and syphilis. Despite this, this study was conducted because there are a limited number of publications that describe GBMSM's knowledge of, and interest in, taking DoxyPEP and preferences regarding its implementation.
View Article and Find Full Text PDFAnn Ig
January 2025
Department of Experimental Medicine, University of Salento, Lecce, Complesso Ecotekne, Lecce, Italy.
Background: Correct information is an essential tool to guide thoughts, attitudes, daily choices or more important decisions such as those regarding health. Today, a huge amount of information sources and media is available. Increasing possibilities of obtaining data also require understanding and positioning skills, particularly the ability to navigate the ocean of information and to choose what is best without becoming overwhelmed.
View Article and Find Full Text PDFJ Phys Chem B
January 2025
Chemistry Department, Western Washington University, Bellingham, Washington 98225-9038, United States.
During the blood coagulation cascade, coagulation factor VIII (FVIII) is activated by thrombin to form activated factor VIII (FVIIIa). FVIIIa associates with platelet surfaces at the site of vascular damage to form an intrinsic tenase complex with activated factor IX. A working model for FVIII membrane binding involves the association of positively charged FVIII residues with negatively charged lipid headgroups and the burial of hydrophobic residues into the membrane interior.
View Article and Find Full Text PDFSci Prog
January 2025
UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
The recent severe acute respiratory syndrome coronavirus 2 pandemic has clearly exemplified the need for broad-spectrum antiviral (BSA) medications. However, previous outbreaks show that about one year after an outbreak, interest in antiviral research diminishes and the work toward an effective medication is left unfinished. Martin et al.
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