Clinical dose calculations are often performed by scaling distances from a dose distribution measured in one medium to calculate the dose in another. These perturbation calculations have the mathematical form of a mapping. In this paper we identify five conditions required for particle transport to reduce to this form and develop a new mapping for electrons which approximately satisfies these conditions. This continuous scattering mapping is based on two parameters, the scattering power of the medium which determines the shape of the scaling paths, and the stopping power of the medium which determines where the energy is deposited along these paths. Pencil beam dose distributions are calculated with EGS4 in one medium and mapped to other media. The resultant distributions are compared with EGS4 calculations done directly in the second medium. The accuracy of the mapping algorithm is shown to be superior to both linear density scaling and the MDAH electron pencil beam algorithm [Kenneth R. Hogstrom, Michael D. Mills, and Peter R. Almond, "Electron beam dose calculations," Phys. Med. Biol. 26, 445-459 (1981)] for pencil beams in homogeneous media and inhomogeneous phantoms (both slab and nonslab geometries) for a variety of materials of clinical interest.
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http://dx.doi.org/10.1118/1.598384 | DOI Listing |
Assessing and alleviating pain in animals involved in research is critically important. However, the effective implementation of pain management depends on the knowledge and attitudes of the personnel involved. Following a Federation of European Laboratory Animal Science Associations 'Pain in Mice' working group initiative, a questionnaire to survey current practices concerning analgesic use in laboratory mice was distributed to several professional groups in the field of laboratory animal science.
View Article and Find Full Text PDFJVS Vasc Insights
October 2024
Division of Vascular Surgery, University of Pittsburgh.
Objective: Antithrombotic therapy improves endovascular intervention outcomes for peripheral artery disease. However, there are limited data guiding the choice and duration of these adjuvant therapies. Thus, we explored current antithrombotic prescribing preferences among vascular interventionalists, hypothesizing that there are varied and inconsistent treatment practices among providers.
View Article and Find Full Text PDFArch Endocrinol Metab
January 2025
Jamia Hamdard School of Chemical & Life Sciences Department of Biotechnology New Delhi India Department of Biotechnology, School of Chemical & Life Sciences, Jamia Hamdard, New Delhi.
Objective: This study aims to explore the role of estrogen in providing cardioprotective benefits to premenopausal women, examining how hormonal differences between sexes influence the prevalence of cardiovascular diseases (CVDs) in women.
Materials And Methods: Eighteen female Wistar rats were equally distributed into three treatment groups. Animals in Group I (sham-operated) and Group II (ovariectomized [OVX]) received oral saline solution at a dose of 2 mL/kg.
Front Oncol
January 2025
Department of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Purpose: This study aimed to provide quantitative information for implementing Lattice radiotherapy (LRT) using a medical linear accelerator equipped with the Millennium 120 multi-leaf collimator (MLC). The research systematically evaluated the impact of varying vertex diameters and separations on dose distribution, peak-to-valley dose ratio (PVDR), and normal tissue dose.
Methods: A cylindrical Virtual Water™ phantom was used to create LRT treatments using the Eclipse version 16.
Drug Test Anal
January 2025
KL Maddy Equine Analytical Chemistry Lab (Pharmacology Section), School of Veterinary Medicine, University of California, Davis, California, USA.
Pharmacokinetics is the study of the movement of drug in the body and includes the processes of absorption, distribution, metabolism, and excretion. Pharmacodynamics is the pharmacologic effect of the drug on the body. The pharmacokinetics of a drug determines its pharmacologic effect.
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