Inherited disorders of keratinization can result in a wide variety of clinical features. The skin is usually affected with blistering or ichthyosis, but other body systems may be involved. The severity of these disorders varies greatly. This article reviews the advances in the molecular pathology of these disorders, and shows how this has benefited our understanding of cell biology.
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Sex-Specific Clinical and Genetic Factors Associated With Adverse Outcomes in Hypertrophic Cardiomyopathy.
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Garvan Institute of Medical Research, University of New South Wales, Sydney, Australia. (A.B., J.S., A.C., J.I.).
Background: Females with hypertrophic cardiomyopathy present at a more advanced stage of the disease and have a higher risk of heart failure and death. The factors behind these differences are unclear. We aimed to investigate sex-related differences in clinical and genetic factors affecting adverse outcomes in the Sarcomeric Human Cardiomyopathy Registry.
View Article and Find Full Text PDFInjecting hope: the potential of intratumoral immunotherapy for locally advanced and metastatic cancer.
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Despite enormous progress, advanced cancers are still one of the most serious medical problems in current society. Although various agents and therapeutic strategies with anticancer activity are known and used, they often fail to achieve satisfactory long-term patient outcomes and survival. Recently, immunotherapy has shown success in patients by harnessing important interactions between the immune system and cancer.
View Article and Find Full Text PDFExploration of the mechanism of tetramethoxyflavone in treating osteoarthritis based on network pharmacology and molecular docking.
Tzu Chi Med J
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Pharmacy College, Gannan Medical University, Ganzhou, Jiangxi, China.
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