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Culture, morality and individual differences: comparability and incomparability across species.
Philos Trans R Soc Lond B Biol Sci
April 2018
Department of Psychology, University of Oregon, 1227 University of Oregon, Eugene, OR 97403, USA
Major routes to identifying individual differences (in diverse species) include studies of behaviour patterns as represented in language and neurophysiology. But results from these approaches appear not to converge on some major dimensions. Identifying dimensions of human variation least applicable to non-human species may help to partition human-specific individual differences of recent evolutionary origin from those shared across species.
View Article and Find Full Text PDFGastrointestinal Stromal Tumor: May Mimic Adnexal Mass.
Glob J Health Sci
June 2015
Bezmi Alem Vakif University, Medical Faculty, Department of Obstetrics and Gynecology, Istanbul, Turkey.
Gastrointestinal stromal tumors (GISTs) are rare tumor of the gastrointestinal tract. GISTs occur in the entire gastrointestinal tract and may also arise from the retroperitoneum, omentum and mesenteries. They are originated from gastrointestinal pacemaker cells (Cajal's interstitial cells) and range from benign tumors to sarcomas at all sites of occurrence.
View Article and Find Full Text PDFNovel vaccine concept based on back-boost effect in viral infection.
Vaccine
June 2015
Univ. of Kentucky, Microbiology/Immunology, 800 Rose Street, Lexington, KY 40536, United States. Electronic address:
A novel vaccine concept is discussed based on recent evidence of a "back-boost" effect in Influenza infection. The initial immune response to the infection is imprinted through an immune memory pathway. The immune memory in the back-boost mechanism could be used in reversed order as a "forward-boost" in the proposed vaccine concept.
View Article and Find Full Text PDFXenoepitope substitution avoids deceptive imprinting and broadens the immune response to foot-and-mouth disease virus.
Clin Vaccine Immunol
April 2012
Center of Excellence for Vaccine Research, University of Connecticut, Storrs, Connecticut, USA.
Many RNA viruses encode error-prone polymerases which introduce mutations into B and T cell epitopes, providing a mechanism for immunological escape. When regions of hypervariability are found within immunodominant epitopes with no known function, they are referred to as "decoy epitopes," which often deceptively imprint the host's immune response. In this work, a decoy epitope was identified in the foot-and-mouth disease virus (FMDV) serotype O VP1 G-H loop after multiple sequence alignment of 118 isolates.
View Article and Find Full Text PDFHeterotypic humoral and cellular immune responses following Norwalk virus infection.
J Virol
February 2010
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Norovirus immunity is poorly understood as the limited data available on protection after infection are often contradictory. In contrast to the more prominent GII noroviruses, GI norovirus infections are less frequent in outbreaks. The GI noroviruses display very complex patterns of heterotypic immune responses following infection, and many individuals are highly susceptible to reinfection.
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