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Significant response to tocilizumab in a case of immune deposits-related membranoproliferative glomerulonephritis and tubulointerstitial nephritis complicated by multicentric Castleman's disease.
Clin Nephrol Case Stud
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Nephrology Center and the Okinaka Memorial Institute for Medical Research.
A 47-year-old woman with a 12-year history of anemia and high C-reactive protein (CRP) levels was admitted to our hospital with worsening fatigue and night sweats. She had high levels of immunoglobulin G (IgG; 4182 mg/dL), IgA (630.6 mg/dL), and CRP (7.
View Article and Find Full Text PDFProtective role of vitamin B6 on some histological changes in the liver and kidneys and measure some indicators of oxidation balance in male rats.
Cell Mol Biol (Noisy-le-grand)
November 2024
Biology Department, College of Education for Pure Sciences, University of Anbar, Iraq.
This study aimed to evaluate the therapeutic effects of B6 in rats experimentally intoxicated by benzopyrene. Twenty-eight Male Sprague Dawley (white Swiss) rats weighing 170-210 g and 3-4 months old were utilized in this examination. Rats were divided into 4 control groups (G1), B[a]P 2 pmol/μL (G2), B6 only once per 2 days for a full month at 1000 mcg (15 dose per month) (G3), B6 + B[a]P (G4).
View Article and Find Full Text PDFProceedings of the 2024 Division of Translational Toxicology Satellite Symposium.
Toxicol Pathol
December 2024
Wake Forest University, Winston-Salem, North Carolina, USA.
The 2024 annual Division of Translational Toxicology (DTT) Satellite Symposium, entitled "Pathology Potpourri," was held in Baltimore, Maryland, at the Society of Toxicologic Pathology's 42nd annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This article presents summaries of the speakers' talks along with select images that were used by the audience for voting and discussion.
View Article and Find Full Text PDFDelayed diagnosis of angioimmunoblast T-cell lymphoma presenting with immunoglobulin a vasculitis.
Ren Fail
December 2024
Department of Nephrology, Affiliated Hospital of Jining Medical College, Jining, China.
Although vasculitis and renal involvement might be associated with malignancy, they are rarely associated with lymphoproliferative diseases. We observed a case of immunoglobulin A vasculitis associated with segmental and focal glomerulonephritis in a patient with Angioimmunoblastic T-cell lymphoma. The most interesting aspect of this case is that this patient's main initial manifestations were skin rash and fever.
View Article and Find Full Text PDFPromising response of proliferative glomerulonephritis with monoclonal IgG deposits to low-dose daratumumab: a case report.
Front Med (Lausanne)
July 2024
Department of Nephrology, Zhejiang Provincial People's Hospital Bijie Hospital, Bijie, Guizhou, China.
Article Synopsis
- Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is a rare condition lacking standardized treatment, but daratumumab, an anti-CD38 antibody, shows promise as a safe and effective option.
- A 66-year-old female patient experienced significant edema and renal issues, with a biopsy revealing specific abnormalities in her glomeruli and deposits of various immunoglobulins.
- After receiving daratumumab, along with prednisone and valsartan, the patient achieved complete remission within three months, marking an initial but hopeful step towards effective PGNMID treatment, though ongoing follow-up is necessary.
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